Antioxidant and Hypolipidemic Activity of Clerodendranthus Spicatus (Thunb.) Water Extracts: A Potential Anti-Aging Mechanism

36 Pages Posted: 1 Feb 2024

See all articles by Xian Xiao

Xian Xiao

Hainan University

Fanhua Wu

Hainan University

Bing Wang

Hainan University

Zeping Cai

Hainan University

Lan-ying Wang

Hainan University

Yun-fei Zhang

Hainan University

Xudong Yu

Hainan University

yanping Luo

Hainan University

Abstract

E thnopharmacological relevance Clerodendranthus spicatus (Thunb.) (Kidney tea) is a perennial herb or subshrub of theLamiaceae, also commonly known as "maoxucao". Because of its important diuretic, anti-stone and kidney protection effects, it is a very distinctive ethnic herbal medicine in China. It is traditionally used as a functional food to treat kidney inflammation, dysuria and diabetes in many countries, and its leaves are widely used as healthy tea for tonifying kidney.A ims of this studyMany previous studies have demonstrated its various longevity-promoting effects, including neuroprotective, anticancer and antioxidant properties. However, the safety and specific health-promoting effects of Clerodendranthus spicatus as a dietary supplement remain unclear. In order to understand the effect of Clerodendranthus spicatus on the longevity of Caenorhabditis elegans (C. elegans), we evaluated its role in C. elegans.M aterials and methods Clerodendranthus spicatus water extracts were prepared, analyzed for their major components and their effects on C. elegans were investigated from physiological and biochemical to molecular levels.R esultsClerodendranthus spicatus water extract (CSw) contains significant phenolic components (primarily rosmarinic acid and eugenolinic acid) and flavonoids (primarily quercetin and isorhamnetin) and can increase the lifespan of C. elegans. Lipofuscin and reactive oxygen species in C. elegans were also decreased by CSw. Further investigations showed that CSw modulates stress resistance and lipid metabolism through influencing DAF-16, HSF-1, and NHR-49 signalling pathways and gene expression (e.g., sod-3, ctl-1, hsp-16.2, and acs-2).c onclusionsClerodendranthus spicatus is suitable for daily consumption as a health tea.

Keywords: Caenorhabditis elegans, Clerodendranthus spicatus, antiaging, antioxidant, Resistance

Suggested Citation

Xiao, Xian and Wu, Fanhua and Wang, Bing and Cai, Zeping and Wang, Lan-ying and Zhang, Yun-fei and Yu, Xudong and Luo, yanping, Antioxidant and Hypolipidemic Activity of Clerodendranthus Spicatus (Thunb.) Water Extracts: A Potential Anti-Aging Mechanism. Available at SSRN: https://ssrn.com/abstract=4705202 or http://dx.doi.org/10.2139/ssrn.4705202

Xian Xiao

Hainan University ( email )

No. 58, Renmin Avenue
570228, P.R.
Haikou, HainanProvince
China

Fanhua Wu

Hainan University ( email )

No. 58, Renmin Avenue
570228, P.R.
Haikou, HainanProvince
China

Bing Wang

Hainan University ( email )

No. 58, Renmin Avenue
570228, P.R.
Haikou, HainanProvince
China

Zeping Cai

Hainan University ( email )

No. 58, Renmin Avenue
570228, P.R.
Haikou, HainanProvince
China

Lan-ying Wang

Hainan University ( email )

No. 58, Renmin Avenue
570228, P.R.
Haikou, HainanProvince
China

Yun-fei Zhang

Hainan University ( email )

No. 58, Renmin Avenue
570228, P.R.
Haikou, HainanProvince
China

Xudong Yu

Hainan University ( email )

No. 58, Renmin Avenue
570228, P.R.
Haikou, HainanProvince
China

Yanping Luo (Contact Author)

Hainan University ( email )

No. 58, Renmin Avenue
570228, P.R.
Haikou, HainanProvince
China

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