Molecular Dynamics Meet Central Dogma: Decoding the Complexity of Lung Cancer for Therapy

Abstract

The treatment of lung cancer, a leading cause of cancer-related deaths worldwide, presents a complex challenge that necessitates a comprehensive understanding of its molecular dynamics and underlying mechanisms. This study introduces a groundbreaking approach that integrates molecular dynamics with the central dogma, offering a new perspective on decoding the intricacies of lung cancer. Focusing on the potential for therapeutic interventions, particularly in the molecular realm, our research addresses three critical issues: the interplay of oncogenes and antioncogenes, drug resistance mechanisms, and the accelerated growth of tumours post-treatment. By analysing the stability and balance of expressed mRNAs and proteins, we explored their profound impact on cancer occurrence, development, and treatment. This study also involved the investigation the structural and functional variations in oncogenes and antioncogenes under environmental stress. Furthermore, in our research, we explored the underlying resistance mechanisms, unravelling how genetic changes manifest through protein structures and lead to drug resistance. We also examined the role of centromeres and telomeres in chromosomal stability and their significance in cancer occurrence. The structure and dynamics of proteins, regarded as cellular workhorses, in response to stimuli were scrutinized, forming a critical link between gene mutations and protein structures. Building upon insights gained from liver cancer and glioma studies, we compared the characteristics of lung cancer-related proteins, specifically oncogenes and antioncogenes. This comprehensive analysis involved molecular and structural methods, providing a nuanced understanding of protein dynamics across various cancers. We employed data from the Human Protein Atlas, encompassing a diverse dataset of lung cancer patients, to assess 20 oncogenes and 20 antioncogenes. The results of this study could lead to valuable insights into the mechanisms and development of lung cancer, paving the way for the design of new diagnostic and treatment methods. Ultimately, this research seeks to inform the development of targeted therapies, offering hope for more effective strategies in the battle against lung cancer.

Funding: The authors declare that there have been no funding used for this manuscript.

Declaration of Interest: The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this study.

Keywords: Lung Cancer; Molecular Dynamics; Central Dogma; Microenvironment; Therapy