Indolent CD8-Positive T-LPD of the Peripheral Nervous System in a 19-Year-Old Man

Abstract

A 19-year-old man presented with recurrent intermittent fever, progressive limbs weakness, numbness, and atrophy for 5 years. The biopsy of the sural nerve, spleen, lymph nodes, bone marrow and labial gland demonstrated that monomorphic small lymphoid cells infiltrated diffusely and that there was severe loss of large myelinated nerve fibers. Immunohistochemically, these cells were mainly CD8-positive T cells and positive for CD3 and CD57. This case was diagnosed as indolent CD8-positive T lymphoproliferative disorder (indolent CD8-positive T-LPD), emphasizing the need for a broad differential diagnosis in this condition, and nerve biopsy should be performed.

Note:
Funding declaration: This project is supported by the National Natural Science Foundation of China (No. 81870889 and 81571086), the Basic Research Project of Shanghai Sixth People’s Hospital (ynms202209), the Shanghai Science and Technology Innovation Action Plan (23DZ2291500), and the Scientific Research Project Fund of Colleges and Universities in Anhui Province (2022AH050680).

Conflict of Interests: None.

Ethical Approval: Written informed consent was obtained from the individuals to publish any potentially identifiable images or data in this article.

Keywords: CD8, T-cell lymphoproliferative disorder, neurolymphomatosis, chronic inflammatory demyelinating polyneuropathy, peripheral neuropathy