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Laminin Expression in Nasopharyngeal Carcinoma and its Serum Levels Indicating its Potential as an Early Prognostic Biomarker
27 Pages Posted: 12 Apr 2024
More...Abstract
Backgrounds: The prognosis of nasopharyngeal carcinoma (NPC) is often complicated by a highincidence of distant metastasis and local treatment failure, resulting in patient death. Our goal is to explore early prognostic biomarkers that can offer a time window for administeringpersonalized therapy tailored in advance to NPC patient at high risk of recurrence.
Methods: In a study involving 46 cases, laminin expression in cancer tissue and serumlaminin levels were investigated through immunohistochemistry and enzyme-linkedimmunosorbent assay, respectively. The patients were followed up for 5 years.
Results: Of particular significance were the findings pertaining to the recurrent and death group,where the rates of laminin staining (42.86%, 38.46%) were notably lower compared to theircounterparts (77.78%, 80%), respectively. Intriguingly, serum laminin concentrations in the recurrentand death group (0.688±0.225, 0.695±0.253) were higher than those in their counterparts. Thisdiscrepancy underscores the potential prognostic value of laminin expression in NPC.Notably, the concentration before radiotherapy (0.642±0.247g/L) surpassed that afterradiotherapy (0.235±0.221g/L), suggesting a potential therapeutic impact on laminin levels.Intriguingly, in the recurrent group, serum laminin elevation occurred approximately 2 monthspreceding the relapse confirmed by CT scan. This temporal association suggests the feasibility of utilizingserum laminin levels as an early indicator of disease recurrence.
Conclusion：the study elucidates the potential utility of laminin expression/serum levels as a valuablebiomarker for predicting illness progression and recurrence. Within a 2-month time window, high-riskNPC patients can receive personalized preventive therapy before the tumor becomes detectable on a CTscan.
Funding: This research is supported by Fujian Province Natural Science Grant 2019J01622.
Declaration of Interest: We declare that there is no competing financial interests in relation to the work described. There is no conflict of interests at all.
Ethical Approval: The current study has been approved by Research Ethics Service and Research Ethics Committees of Mindong Hospital, the code is 202404011445000598668.
Keywords: Nasopharyngeal carcinoma, laminin
Suggested Citation: Suggested Citation