Visible-Light-Mediated Photoredox Giese Reaction with Α-Branched 2-Vinylpyridines and Α-Ketoacids

Abstract

A visible-light-mediated photoredox Giese reaction with α‑branched 2‑vinylpyridines and α-ketoacids is described. This reaction relies on the use of readily accessible and stable α-ketoacids to achieve the hydroacylation of α‑branched 2‑vinylpyridines, providing a mild and efficient method for the synthesis of pyridine derivatives. The reactions of various α‑branched 2‑vinylpyridines with α-ketoacids show the generality of this method.

Keywords: Photoredox, Giese reaction, Pyridine, α-ketoacids