Fluoride Exposure and its Interaction with Atp2b1 Polymorphism in The Disorder of Lipid Metabolism in Adults

Abstract

Long-term exposure to excessive fluoride can lead to fluorosis. Animals research, epidemiological survey of children and adolescents find a significant association between fluoride and lipid metabolism. However, this relationship is still unclear in adults. We conducted a cross-sectional study. Based on this study, we found the urinary fluoride concentration was positively associated with the serum ApoA1 decrease, but negatively with ApoB elevation. Sensitivity analysis showed similar results between urinary fluoride concentration and serum ApoA1 decreas, ApoB elevation when excluded hypertension and diabetes mellitus. Stratified analysis showed urinary fluoride was positively associated with serum ApoA1 decrease in mostly stratification, except alcohol drinking and smoking. Genetic analysis found rs12817819 with a carrier of the T allele was a protective factor for serum ApoA1 decrease, rs17249754 with a carrier for the A allele and rs7136259 with a carrier for the T allele were risk factors for serum ApoA1 decrease. Interactive analysis found the urinary fluoride concentration which was lower than 0.9 mg/L had an interaction effect with the rs7136259 for carriers of the T allele in serum ApoA1 decrease. Hence, we think the fluoride exposure may be associated with in serum ApoA1 decrease and ApoB elevation in adults. The polymorphism of ATP2B1 rs12817819, rs17249754, and rs7136259 are associated with serum ApoA1 decrease and LDL-C elevation. In addition, there is an interaction effect between fluoride exposure which is lower than 0.9 mg/L and the ATP2B1 rs7136259 in serum ApoA1 decrease.

Note:
Funding Declaration: This work was supported by the National Key R&D Program of China（2022YFC2503000）.

Conflicts of Interest: None.

Ethical Approval: All participants signed a written informed consent form. This research was approved by the Ethical Review Boards of the Center for Endemic Disease Control and Chinese Center for Disease Control and Prevention (No. hrbmuecdc20210303).

Keywords: ATP2B1, fluoride, lipid metabolism