Recapitulating Maternal-Fetal Interactions Using Stem Cell Derived Placental Organoids

Abstract

In this study, we present a comprehensive comparison of methods for generating placenta-like organoids derived from stem cells, aiming to mimic the transient yet vital functions of the placenta. These organoids, composed of diverse cell types, actively secrete crucial cytokines, hormones, and factors involved in vascular modulation. Our findings showcase the potential of these organoids as a robust platform for in vitro modeling of early-stage human development and maternal-fetal interfaces. Furthermore, we demonstrate their utility in various applications, including the study of extra-embryonic tissue development, elucidation of placental-vascular interactions, investigation of implantation processes, and assessment of drug toxicity.

Keywords: Stem cells, placenta, organoids, trophoblasts, microfluidics, placenta-on-a-chip