Chemical Composition and Antioxidant Potential of Sage (Salvia Officinalis L.) Cultivated in Dalat, Vietnam

21 Pages Posted: 4 Jun 2024

See all articles by Nguyen Thi-Thuy-My

Nguyen Thi-Thuy-My

Duy Tan University - Duy Tan University, Students

Thi-Thu-Trang Phan

Faculty of Pharmacy, College of Medicine and Pharmacy, Duy Tan University, Da Nang 550000, Vietnam

Thi-Phuong-Thao Pham

HERBITECH Co. LTD HANOI, 100000 VIETNAM

Hai-Anh Ha

Faculty of Pharmacy, College of Medicine and Pharmacy, Duy Tan University, Da Nang 550000, Vietnam

Date Written: June 4, 2024

Abstract

Introduction: Sage (Salvia officinalis L.) is a medicinally significant plant known for its diverse bioactive compounds. This study investigates the bioactive constituents of Sage leaves collected from Da Lat, Vietnam, focusing on flavonoid content, antioxidant activity, essential oil yield, and chemical composition.

Methods: Flavonoid content, a major bioactive component, was determined using quecetin standard line calculation. Antioxidant activity was evaluated using DPPH method. Essential oil was extracted, quantified, and analyzed through gas chromatography-mass spectrometry (GC-MS). Results and discussion: The average total flavonoid content in Sage leaves was found to be 19.955 mg quercetin equivalents per gram of dry matter (mgQE/g), with slight variations among samples. The moderate antioxidant activity of Sage leaves was demonstrated by an IC50 value of 457.597 µg/ml, reflecting the complex relationship between flavonoids and antioxidant potential. Essential oil content in Sage leaves averaged 0.309%. GC-MS analysis identified 18 distinct compounds, with α-thujone (35.96%) and camphor (14.64%) as predominant constituents. These findings emphasize the adaptability of Sage to diverse ecosystems and highlight the multifaceted pharmacological potential of this medicinal plant. Variations in flavonoid content, antioxidant activity, essential oil yield, and chemical composition suggest the influence of geographical and environmental factors.

Conclusion: This study provides insights into bioactive constituents of Sage cultivated in Vietnam, laying the groundwork for further research to explore its potential applications in pharmacopuncture, traditional medicine, and the pharmaceutical industry.

Keywords: Salvia officinalis L., Sage Vietnam, flavonoid, essential oil, antioxidant

Suggested Citation

Thi-Thuy-My, Nguyen and Phan, Thi-Thu-Trang and Pham, Thi-Phuong-Thao and Ha, Hai-Anh, Chemical Composition and Antioxidant Potential of Sage (Salvia Officinalis L.) Cultivated in Dalat, Vietnam (June 4, 2024). Available at SSRN: https://ssrn.com/abstract=4853851 or http://dx.doi.org/10.2139/ssrn.4853851

Nguyen Thi-Thuy-My

Duy Tan University - Duy Tan University, Students ( email )

Vietnam

Thi-Thu-Trang Phan

Faculty of Pharmacy, College of Medicine and Pharmacy, Duy Tan University, Da Nang 550000, Vietnam ( email )

03 Quang Trung
Danang, Danang 550000
Vietnam

Thi-Phuong-Thao Pham

HERBITECH Co. LTD HANOI, 100000 VIETNAM ( email )

Ha Noi
Da Nang
Ha Noi, 100000
Vietnam

Hai-Anh Ha (Contact Author)

Faculty of Pharmacy, College of Medicine and Pharmacy, Duy Tan University, Da Nang 550000, Vietnam ( email )

03 Quang Trung
Danang, Danang 550000
Vietnam

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