BackgroundWe will study basic and advanced features of CMR in 2 groups of HCM patients with negative and positive genotype, respectively.Materials and MethodsThe study population consisted in consecutive HCM patients referred to Centro Cardiologico Monzino who performed both CMR and genetic testing. Clinical CMR images were acquired at 1.5 T Discovery MR450 scanner (GE Healthcare, Milwaukee, Wisconsin)) using standardized protocols T1 mapping, T2 mapping and late gadolinium enhancement (LGE). Population was divided in 2 groups: group 1 with HCM patients with a negative genotype and group 2 with a positive genotypeResultsThe analytic population consisted of 110 patients: 75 in group 1 and 25 patients in group 2.At CMR evaluation, patients with a positive genotype had higher LV mass (136 vs. 116 g, p=0.02), LV thickness (17.5 vs. 16.9 mm), right ventricle ejection fraction (63% vs. 58%, p=0.002).Regarding the LGE patients with positive genotype have a higher absolute (33.8 vs 16.7 g, p=0.0003) and relative LGE mass (31.6% vs 14.6%, p=0.0007). On a segmental analysis all the septum (segments 2, 8, 9, and 14) had a significantly increased native T1 compared to others segments. ECV in the mid antero and infero-septum (segments 8 and 9) have lower values in positive genotype HCM. Interestingly the mean T2 was lower in positive genotype HCM as compared to negative genotype HCM (50,1 ms vs 52,4).ConclusionsOur paper identifies the mid septum (segments 8 and 9) as a key to diagnose a positive genotype HCM
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Funding Information: None.
Declaration of Interests: All authors have no conflict of interest.
Ethics Approval Statement: The Centro Cardiologico Monzino’s ethical committee approved the protocol and all patients gave written informed consent.
mushtaq, saima and chiesa, mattia and novelli, valeria and sommariva, elena and biondi, maria luisa and manzoni, martina and fiorio, alessio and Lampus, maria luisa and avallone, carlo and zocchi, chiara and ianniruberto, monica and zannoni, jessica and nudi, alessandro and arcudi, alessandra and annoni, andrea and baggiano, andrea and berna, Giovanni and carerj, maria ludovica and cannata, francesco and celeste, fabrizio and del torto, alberico and fazzari, fabio and formenti, alberto and frappampina, antonio and fusini, laura and ghulam ali, sarah and gripari, paola and pizzamiglio, francesca and Ribatti, Valentina and junod, daniele and maltagliati, anna and mancini, maria elisabetta and mantegazza, valentina and Maragna, Riccardo and marchetti, francesca and sbordone, paolo and muratori, manuela and tassetti, luigi and volpe, alessandra and saba, luca and Autore, Camillo and olivotto, jacopo and guaricci, andrea igoren and Andreini, Daniele and pontone, gianluca, Role of Advanced Cmr Features in Identifying a Positive Genotype of Hypertrophic Cardiomyopathy. Available at SSRN: https://ssrn.com/abstract=4869002 or http://dx.doi.org/10.2139/ssrn.4869002
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