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A Predictive Model for Continuous Myopia Progression Using Stacking Algorithm and Shapley Additive Explanations in Southern China: A Retrospective Cohort Study

18 Pages Posted: 25 Jun 2024

See all articles by Man Luo

Man Luo

Peking University

Yingting Zhu

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Wenjing Han

Capital Medical University

Chen Zhou

Capital Medical University

Zhidong Li

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Jieying Guan

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Shaofen Huang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Rui Xie

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Ruiyu Luo

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Guitong Ye

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Yuan Zhang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Xinyue Shen

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Jianqi Chen

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Lingjing Hu

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Yehong Zhuo

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology

Yizhou Wang

Peking University

More...

Abstract

Background: The prevalence of myopia has rapidly increased in recent decades, which has become a global public health problem.We aimed to explore the risk factors and establish a machine learning (ML) model for myopia progression in children and teenagers through true-world longitudinal data in southern China.

Methods: This retrospective cohort study screened 13,504 children and teenagers aged 6-18 at baseline annually over three years. Data preprocessing was performed using the Synthetic Minority Over-sampling Technique (SMOTE). A continuous myopia progression prediction model was constructed by selecting risk factors through stepwise logistic regression and employing a stacking ensemble algorithm for ML integration. The results were visualized using Shapley Additive Explanations (SHAP), and an online app was developed using the Streamlit tool.

Findings: Among the 45 ML model combinations, the Stochastic Gradient Descent + Random Forest model demonstrated the highest discriminative ability, with an average accuracy of 0.902 and an AUROC of 0.951. Further visualizations using SHAP revealed that the contribution of risk factors was ranked in the following order: age, non-cycloplegic spherical equivalent, uncorrected distance visual acuity, school type, and gender. These findings were then translated into an online tool designed for clinical application.

Interpretation: This study established an explainable ML model with high accuracy in predicting continuous myopia progression. Additionally, the model visualization and the development of an online app tool facilitate more convenient clinical monitoring of myopia progression.

Trial Registration: Registered with the Chinese Clinical Trial Registry (ChiCTR2200057391).

Funding: "the National Key R&D Project of China [grant number 2020YFA0112701, Yehong Zhuo];
the National Natural Science Foundation of China [grant number 62061136001, Yizhou Wang];
the Science and Technology Program of Guangzhou, China [grant number 202206080005, Yehong Zhuo]; the Natural Science Foundation of Guangdong Province [grant number 2024A1515013058, Yingting Zhu]."

Declaration of Interest: All authors declare no potential conflicts of interest.

Ethical Approval: This longitudinal cohort study was approved by the Ethics Committee of Sun Yat-sen University, Guangzhou, China (No.2021KYPJ185). Written informed consent was not required as no identifying information was recorded.

Keywords: Continuous progression of myopia, Children and adolescent, machine learning, Predictive model, SHAP

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Suggested Citation

Luo, Man and Zhu, Yingting and Han, Wenjing and Zhou, Chen and Li, Zhidong and Guan, Jieying and Huang, Shaofen and Xie, Rui and Luo, Ruiyu and Ye, Guitong and Zhang, Yuan and Shen, Xinyue and Chen, Jianqi and Hu, Lingjing and Zhuo, Yehong and Wang, Yizhou, A Predictive Model for Continuous Myopia Progression Using Stacking Algorithm and Shapley Additive Explanations in Southern China: A Retrospective Cohort Study. Available at SSRN: https://ssrn.com/abstract=4872351 or http://dx.doi.org/10.2139/ssrn.4872351

Man Luo

Peking University ( email )

No. 38 Xueyuan Road
Haidian District
Beijing, 100871
China

Yingting Zhu

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Wenjing Han

Capital Medical University ( email )

Chen Zhou

Capital Medical University ( email )

Zhidong Li

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Jieying Guan

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Shaofen Huang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Rui Xie

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Ruiyu Luo

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Guitong Ye

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Yuan Zhang

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Xinyue Shen

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Jianqi Chen

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Lingjing Hu

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Yehong Zhuo (Contact Author)

Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology ( email )

Yizhou Wang

Peking University ( email )

No. 38 Xueyuan Road
Haidian District
Beijing, 100871
China

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