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Development Deficiency of Oligodendrocyte and Myelination in the Central Nervous System of the Fetal Alcohol Syndrome Mouse Model

27 Pages Posted: 23 Jul 2024 Publication Status: Preprint

See all articles by Xiaoling Liang

Xiaoling Liang

Zunyi Medical University

Rulan Yi

Zunyi Medical University

Xu Wang

Zunyi Medical University

Fu-Wang Zhong

Zunyi Medical University

Yali Lu

Zunyi Medical University

Wenjia Chen

Zunyi Medical University

Ning Zhang

Zunyi Medical University

Tian Yu

Zunyi Medical University

Liang Zhou

Zunyi Medical University - Key Laboratory of Brain Science

Abstract

Fetal alcohol spectrum disorder (FASD) is a severe condition characterized by physical and neurodevelopmental abnormalities in the fetus resulting from prenatal alcohol exposure (PAE). Behavioral abnormalities associated with white matter damage have been extensively investigated in FASD patients and animal models, which suggested the involvement of myelination in the FASD pathology. However, the impact of FASD on oligodendrocytes (OLs) and myelination within the central nervous system (CNS) and the underlying mechanisms are little discovered. Here, we showed impaired myelination in the CNS of the male FASD mouse model, which is associated with hyperactivity-like behaviors, whereas the female FASD mice exhibit delayed myelin formation and normal behaviors. Furthermore, myelination deficiency in FASD is due to the inhibition of oligodendrocyte precursors (OPCs) proliferation. Additionally, FASD exerts an impact on the quantity and differentiation of redial glia cells (RGCs), which may contribute to the defect of oligodendrocytes development and myelination. Together, our data reveals the deficiency of oligodendrocyte development and myelination in the CNS of the FASD mouse model and the possible underlying mechanism, suggesting a potential therapy target for FASD.

Note:
Funding declaration: This work was supported by National Natural Science Foundation of China (82060224), Scientific Project of Guizhou Province (Qian Comprehensive Basic Science [2020]1Y088, [2017]5733-066, [2020]-002), and PhD research startup foundation of Zunyi medical University (F-958).

Conflict of Interests: The authors claim no conflicts of interest.

Ethical Approval: This study was approved by the Animal Experimental Ethics Committee of Zunyi Medical University, and all animals met the ethical requirements.

Keywords: Fetal Alcohol Syndrome, Prenatal alcohol exposure, myelination, oligodendrocytes, Redial Glia Cells

Suggested Citation

Liang, Xiaoling and Yi, Rulan and Wang, Xu and Zhong, Fu-Wang and Lu, Yali and Chen, Wenjia and Zhang, Ning and Yu, Tian and Zhou, Liang, Development Deficiency of Oligodendrocyte and Myelination in the Central Nervous System of the Fetal Alcohol Syndrome Mouse Model. Available at SSRN: https://ssrn.com/abstract=4891867 or http://dx.doi.org/10.2139/ssrn.4891867

Xiaoling Liang

Zunyi Medical University ( email )

Zunyi
China

Rulan Yi

Zunyi Medical University ( email )

Xu Wang

Zunyi Medical University ( email )

Zunyi
China

Fu-Wang Zhong

Zunyi Medical University ( email )

Zunyi
China

Yali Lu

Zunyi Medical University ( email )

Zunyi
China

Wenjia Chen

Zunyi Medical University ( email )

Zunyi
China

Ning Zhang

Zunyi Medical University ( email )

Zunyi
China

Tian Yu

Zunyi Medical University ( email )

Zunyi
China

Liang Zhou (Contact Author)

Zunyi Medical University - Key Laboratory of Brain Science ( email )

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