Tigecycline Combined with Bronchoscopic Interventions in the Treatment of Macrolide-Unresponsive Mycoplasmoides Pneumoniae Pneumonia：A Case Report

Abstract

Mycoplasmoides pneumoniae (Mycoplasma pneumoniae; MP) is a frequent cause of community-acquired pneumonia, which is typically mild. However, there has been an increasing incidence of macrolide-unresponsive Mycoplasmoides pneumoniae pneumonia (MUMPP) in recent years. The treatment of MUMPP remains to be further explored. In this report, we present a case of MUMPP with the secondary spontaneous pneumothorax. The patient's condition significantly improved after receiving a novel tetracycline, broad-spectrum β-lactam antibiotic, glucocorticoid and bronchoscopic interventions. Symptomatic supportive measures, including supplemental oxygen, was provided for the management of spontaneous pneumothorax. This is the first report on tigecycline combined with bronchoscopic interventions including bronchoalveolar lavage (BAL) and bronchoscopic cryotherapy (BC) in the treatment of MUMPP, glucocorticoid can be considered for anti-inflammatory purposes if deemed necessary, especially for patients with severe pneumonia. The present case provides insights into a potential treatment option for patients with MUMPP.

Note:
d Funding Information: This research was supported by the Program of The National Natural Science Foundation of China (No.81900092).

Conflict of Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Ethical Approval: The study was approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (TJ-IRB20230515). Written informed consent has been obtained from the patient and the guardians to publish this paper.

Keywords: Mycoplasmoides pneumoniae pneumonia, macrolide-unresponsive, tigecycline, bronchoscopic interventions, Case report