A Metal-Organic Framework with Chemodynamic Performance Self-Synergistic Efficient Near-Infrared Photothermal Activities for in Vivo Antibacterial Application

Abstract

The overuse of antibiotics leads to the increasing drug resistance of bacteria. The development and utilization of non-antibiotic antibacterial agents have attracted extensive attention. In this paper, a single metal-organic framework CHMOF itself with excellent photothermal and photodynamic properties was constructed based on Cu+/Cu2+ metal nodes and 2,3,6,7,10,11-hexahydroxytriphenylene ligand. The efficient near-infrared photothermal activities and the self-synergistic Fenton effect make it exhibit excellent antibacterial performance. In the in vitro antibacterial test, the bactericidal rate of CHMOF against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in the self-synergistic antibacterial mode was greater than 99.999%. The effectively self-synergistic antibacterial performance of this multifunctional MOF was further successfully verified upon in vivo antibacterial application.

Keywords: Metal−organic framework, Near-Infrared Photothermal, Chemodynamic, Self-synergistic treatment, Antibacterial application