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Impact of Long-Term N-Acetylcysteine Use on Cancer Risk Among COPD Patients
47 Pages Posted: 21 Aug 2024
More...Abstract
Purpose: Chronic obstructive pulmonary disease (COPD) patients face an increased risk of developing various malignancies due to shared risk factors and underlying systemic inflammation. N-acetylcysteine (NAC) has shown potential anticancer properties in preclinical studies, but clinical evidence in COPD patients is limited.
Patients and Methods: We conducted a nationwide propensity score-matched cohort study using data from Taiwan's National Health Insurance Research Database to evaluate the anticancer effects of NAC in COPD patients. Patients diagnosed with COPD between 2008 and 2019 were included, and those with pre-existing cancer were excluded. NAC use was defined as consistent administration for most days with an average dose exceeding 28 cumulative defined daily doses (cDDDs) annually. Cox regression models were adjusted for various covariates was employed.
Keywords: N-acetylcysteine, COPD, Cancer risk, Chemoprevention, Dose-dependent
Suggested Citation: Suggested Citation