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Heart Transplantation for Refractory Candida Tropicalis Endocarditis: A Case Report and Literature Review

10 Pages Posted: 19 Sep 2024 Publication Status: Under Review

See all articles by Ricardo El Nouwar

Ricardo El Nouwar

Université Libre de Bruxelles (ULB) - Department of Infectious Disease

Eva Larranaga Lapique

Université Libre de Bruxelles (ULB) - Department of Infectious Disease

Frédéric Vanden Eynden

Université Libre de Bruxelles (ULB)

Delphine Martiny

University of Antwerp - Institute of Tropical Medicine (ITM)

Myriam Remmelink

Université Libre de Bruxelles (ULB)

Ana Roussoulières

Université Libre de Bruxelles (ULB)

Maya Hites

Université Libre de Bruxelles (ULB) - Department of Infectious Disease

Abstract

Candida infective endocarditis presents therapeutic challenges with high mortality. A complex case of Candida prosthetic valve endocarditis refractory to standard therapy and high dose antifungals was successfully treated with heart transplantation. Literature review revealed few similar cases. This report explores heart transplantation as last resort for managing refractory infective endocarditis.

Note:
Funding Information: This work was conducted without funding or grant.

Conflict of Interests: The authors declare no conflicts of interest.

Ethical Approval: We received an approval from our ethical committee at HUB (Hôpital Universitaire de Bruxelles) before leading this project. We obtained an appropriate consent, permissions and releases. The consent is written and signed.

Keywords: Fungal endocarditis, heart transplantation, Antifungal therapy, Candida infection

Suggested Citation

El Nouwar, Ricardo and Larranaga Lapique, Eva and Vanden Eynden, Frédéric and Martiny, Delphine and Remmelink, Myriam and Roussoulières, Ana and Hites, Maya, Heart Transplantation for Refractory Candida Tropicalis Endocarditis: A Case Report and Literature Review. Available at SSRN: https://ssrn.com/abstract=4933930 or http://dx.doi.org/10.2139/ssrn.4933930

Ricardo El Nouwar (Contact Author)

Université Libre de Bruxelles (ULB) - Department of Infectious Disease ( email )

Eva Larranaga Lapique

Université Libre de Bruxelles (ULB) - Department of Infectious Disease ( email )

Frédéric Vanden Eynden

Université Libre de Bruxelles (ULB) ( email )

Delphine Martiny

University of Antwerp - Institute of Tropical Medicine (ITM) ( email )

B-2000 Antwerp
Belgium

Myriam Remmelink

Université Libre de Bruxelles (ULB) ( email )

Ana Roussoulières

Université Libre de Bruxelles (ULB) ( email )

Maya Hites

Université Libre de Bruxelles (ULB) - Department of Infectious Disease ( email )

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