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A Potential Dietary Supplement Strategy Combined with Metabolomics Delivery of Precision Nutrition for Counteracting Pre-Sarcopenia
28 Pages Posted: 26 Sep 2024
More...Abstract
Background: Age-related sarcopenia is due to elevated rates of muscle protein breakdown, reduction in muscle protein synthesis, or combined the two factors. Emerging evidence suggests that the elderly may need to distribute dietary intake evenly throughout the day, to promote muscle protein synthesis and enhance muscle function. Due to factors such as age and genes, individuals have different responses and sensitivity to food or dietary patterns, resulting in different metabolic characteristics.
Methods: From 1200 participants, 449 elderly people were selected to identify sarcopenia characteristics. A subset of 49 with pre-sarcopenia (36 with LMM, 13 with LPF) underwent a 12-week dietary supplement. Body composition, hand grip, and gait speed were used to evaluate muscle mass and function. A metabolomic approach was used to address systemic influences in dietary intervention at 6 weeks and 12 weeks.
Findings: A 12-week dietary supplement improved muscle mass by 55.6% in the LMM group and enhanced physical function by 76.9% in the LPF group. The improved group in LMM had higher BMI, hemoglobin, hematocrit, glucose, and albumin and lower RDW. Dietary supplement increased acylcarnitines (ACs), AC5iso-OH, from branch-chain amino acid catabolism and decreased long-chain ACs from β-oxidation indicate improved mitochondrial activity and enhanced muscle mass and function.
Interpretation: A potential dietary supplement enhances muscle mass and function in elderly people with LMM or LPF. These clinical and metabolic signatures respond to various outcomes. The mechanism insights move the field toward better personalized approaches for a nutritional supplement for preventing sarcopenia.
Funding: The authors acknowledge the data collection, data management, and information technology services, based on the Structured Research and Medical Informatics Cloud (SRMIC) platform system, provided by the Clinical Trial Center, Chang Gung Memorial Hospital, Linkou, Taiwan, R.O.C., with support by the Ministry of Health and Warefare under Grant No. MOHW110-TDU-B-212-124005. This research was supported by Chang Gung Memorial Hospital (grant number: XMRPG3L102, CMRPD1J0263, CMRPD1M0341 and CORPD1P0021), National Science and Technology Council (NSTC) (grant number: 110-2320-B-182-007, 111-2320-B-182-011, 112-2320-B-182-020-MY3, and 113-2622-8-162- 002-TB), Ministry of Education in Taiwan (MOE) (EMRPD1N0581, and EMRPD1L0421) and Chang Gung University (grant number: URRPD1P0141).
Declaration of Interest: The authors declare no conflicts of interest.
Ethical Approval: The study was conducted according to the ethical guidelines of the Declaration of Helsinki and was approved on 11 June 2021 by the Institutional Review Board of Chang Gung Memorial Hospital (202100551A3C501).
Keywords: pre-sarcopenia, metabolome, supplement, prevention
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