Capacitance Electric Fields and Cancer: Exploring the Physics Behind Cellular Vulnerability and Disruption

Abstract

Capacitance electric fields (CEFs) represent a pioneering physics-based approach in cancer therapy, offering selective, non-invasive mechanisms to exploit the biophysical vulnerabilities of malignant cells while preserving normal tissues. This work outlines the fundamental principles by which CEFs interact with cancer cell membranes, leveraging properties such as increased capacitance, altered dielectric characteristics, and ion channel dysregulation. These mechanisms induce membrane polarization, dielectric breakdown, and electroporation, ultimately leading to ionic imbalances and cell death.

Cancer cells, including primary and metastatic types, demonstrate heightened sensitivity to CEF-induced disruption due to their distinct electrophysiological traits, such as increased membrane fluidity and enhanced dielectric susceptibility. In contrast, the stability of normal cells' biophysical properties under CEF exposure underscores the precision and safety of this modality.

This paper also explores the conceptual integration of CEFs with existing oncologic therapies, including chemotherapy, radiotherapy, and immunotherapy, proposing their potential to improve drug delivery, enhance radiosensitivity, and amplify immune responses. By establishing a comprehensive theoretical framework for the application of CEFs, this work bridges disciplines, emphasizing the intersection of physics, biology, and medicine, and laying the foundation for future innovations in selective cancer cell disruption and interdisciplinary biomedical research.

Keywords: Capacitance Electric Fields, Cancer Cell Biophysics, Dielectric Properties, Electroporation, Membrane Capacitance, Primary and Metastatic Cancer