Relationships between Secukinumab Concentrations, Disease Activity, and Il-17a Levels in Psoriasis: A Cross-Sectional Observational Study

Abstract

BackgroundSecukinumab has been approved for the treatment of psoriasis. Off-label high-dose regimens has been used for certain patients. Therapeutic drug monitoring can assist in adjusting treatment plans.AimsThis study aimed to determine the therapeutic threshold of secukinumab and evaluate the influence of patient characteristics on secukinumab concentrations in patients with psoriasis .MethodsPatients with psoriasis (n=36) treated with secukinumab during the maintenance therapy were enrolled in this cross-sectional study. Disease activity was determined using the Psoriasis Area and Severity Index (PASI) with an optimal response (OR) defined as ≤ 2. Secukinumab trough concentrations were measured using an in-house developed sandwich ELISA method.ResultsThe median secukinumab concentrations in patients with OR were significantly higher than in those without (35.08 vs 25.94 μg/mL, P<0.05). Secukinumab levels greater than 35.43 µg/mL were associated with OR (sensitivity of 50.00%, specificity of 89.89%, AUC=0.70, and P<0.05). Multivariate logistic regression showed that secukinumab concentrations was significantly associated with OR (OR 1.02; 95% CI 1.01-1.12; P=0.04). Linear mixed-effects analysis indicated that increase in body weight and decrease in albumin were associated with decrease in secukinumab concentrations. IL-17A levels showed no correlation with PASI score or secukinumab concentrations.ConclusionsSecukinumab concentrations over 35.43 µg/mL were associated with OR in patients with psoriasis . When determining the treatment dose, attention may be paid to patients with higher body weight and lower albumin levels in order to prevent underdosing.

Note:
Funding declaration: This study was funded by the Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee (grant number BJ2023019, BJ2023039).

Conflict of Interests: The authors declare that this study was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

Ethical Approval: This study was approved by the affiliated Wuxi People's Hospital of Nanjing Medical University. All the participants provided written informed consent.

Keywords: secukinumab, therapeutic drug monitoring, ELISA, Psoriasis, IL-17A