Primary Oral Syphilis Presenting as a Nodular Lower Lip Lesion

Abstract

We report the case of a 19-year-old woman who presented with a painless, nodular lesion of the lower lip. A Venereal Disease Research Laboratory (VDRL) test returned positive at a titer of 1:32, confirming the diagnosis of syphilis. Histopathological examination showed endothelial swelling with pericapillary plasmacytic infiltration (Figure 3). The patient was treated successfully with a single intramuscular dose of benzathine penicillin G. Recognition of oral presentations of syphilis is crucial for prompt diagnosis and management preventing further complications and transmission.

Note:
Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Conflict of Interests: The author declare no competing interests.

Consent Statement: Written informed consent was obtained from the patient for publication of this case report and the associated images.

Keywords: Primary syphilisOral syphilisLower lip lesionSexually transmitted infections (STIs)Atypical chancresBenzathine penicillin G therapy