Using Off-the-Shelf Biosensors to Implement Gateways for Alarm-System Nanonetworks

Abstract

DNA-based nanonetworks offer exciting prospects for future biomedical applications, particularly in early disease detection and targeted therapy. However, a major challenge remains in reliably transmitting information from the nanoscale to external monitoring systems. This paper explores the use of commercially available continuous glucose monitoring (CGM) sensors as gateways between in-vivo nanonetworks and external devices. We propose a novel architecture in which DNA-based nanosensors release glucose as a signaling molecule upon detection of disease-relevant biomarkers. These glucose surges can be detected by CGM systems, allowing real-time external communication. After analyzing the suitability of various biosensor types, CGM sensors emerged as the most viable option due to their widespread availability, biocompatibility, and ability to measure biochemical signals. We present several architectural alternatives, calculate the required signal strength for reliable detection, and discuss potential experimental validation strategies. Our findings highlight a feasible and practical pathway toward integrating nanoscale diagnostics with existing biosensing technologies.

Keywords: Biosensors, nanonetwork, continuous glucose monitoring, nanobots, nanonetworks, DNA-based nanonetworks