Juice Powder Concentrate and Systemic Blood Pressure, Progression of Coronary Artery Calcium and Antioxidant Status in Hypertensive Subjects: A Pilot Study

Evidence-Based Complementary and Alternative Medicine, Forthcoming

Posted: 12 Apr 2007

See all articles by Mark C. Houston

Mark C. Houston

Vanderbilt University School of Medicine

Bruce Cooil

Vanderbilt University - Statistics

B.J. Olafsson

The Heart Group

Paolo Raggi

Emory University School of Medicine

Abstract

Because micronutrients from plants may have beneficial cardiovascular effects, the hypothesis that an encapsulated juice powder concentrate might affect several measures of vascular health was tested in free living adults at low cardiovascular risk.

Blood pressure, vascular compliance, lipid and antioxidant markers, and serial electron beam tomography (to calculate a coronary artery calcium score as a measure of atherosclerosis burden), were monitored in 51 pre-hypertensive and hypertensive subjects over two years.

By the end of follow-up, systolic and diastolic blood pressure decreased significantly (-2.4 +/- 5.9 mmHg, p<0.05 and -2.2 +/- 3.5 mmHg, p<0.001), and large artery compliance improved significantly (1.9 +/- 3.6 ml/mmHg x 100, p<0.01). The progression of coronary artery calcium score was smaller than expected compared to a historical database (p<0.001). Laboratory testing showed significant decreases in glycated hemoglobin (p<0.03), homocysteine (p<0.05), HDL cholesterol (p<0.05) and Apo A (p<0.01), as well as significant increases in beta-carotene, folate, Co-Q10 and alpha-tocopherol (all p<0.001).

The phytonutrient concentrate we utilized induced several favorable modifications of markers of vascular health in the study subjects. This study supports the notion that plant nutrients are important components of a heart healthy diet.

Keywords: antioxidant, blood pressure, coronary artery calcium, fruit, hypertension, vegetable

JEL Classification: I12, Z00

Suggested Citation

Houston, Mark C. and Cooil, Bruce and Olafsson, B.J. and Raggi, Paolo, Juice Powder Concentrate and Systemic Blood Pressure, Progression of Coronary Artery Calcium and Antioxidant Status in Hypertensive Subjects: A Pilot Study. Evidence-Based Complementary and Alternative Medicine, Forthcoming. Available at SSRN: https://ssrn.com/abstract=979571

Mark C. Houston (Contact Author)

Vanderbilt University School of Medicine ( email )

Nashville, TN 37232-0685
United States

Bruce Cooil

Vanderbilt University - Statistics ( email )

Nashville, TN 37203
United States

B.J. Olafsson

The Heart Group ( email )

The Heart Group
4230 Harding Road
Nashville, TN 37205
United States

Paolo Raggi

Emory University School of Medicine ( email )

201 Dowman Drive
Atlanta, GA 30322
United States

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