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Richard Gessner

University of Cape Town

Rondebosch

South Africa

  • University of Cape Town

SCHOLARLY PAPERS

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Scholarly Papers (1)

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Targeting HsDHODH for Host-Directed Therapy: Shape and Machine-learning Guided Discovery and Structural Validation of SARS-CoV-2 Antivirals​

Number of pages: 54 Posted: 20 May 2026
Luiza Vieira da Cruz, Sabrina Silva-Mendonça, Aline D. Purificação, Melina Mottin, Miguel Arbeláez, Caroline S. Freitas, Natalia Fintelman-Rodrigues, Mayara Mattos, Thamires Quadros Froes, Christopher Jurisch, Donald Seanego, Grant Boyle, Fernanda de França Genuíno Ramos Campos, Thiago Souza, Richard Gessner, Kelly Chibale, Maria Cristina Nonato and Carolina H. Andrade
affiliation not provided to SSRN, Federal University of Goias, affiliation not provided to SSRN, affiliation not provided to SSRN, Universidad Nacional de Colombia, Fundação Oswaldo Cruz - Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (FIOCRUZ), Fundação Oswaldo Cruz - Instituto Oswaldo Cruz, State University of Feira de Santana, University of Cape Town, University of Cape Town, University of Cape Town, affiliation not provided to SSRN, Oswaldo Cruz Foundation (FIOCRUZ), University of Cape Town, University of Cape Town, affiliation not provided to SSRN and Federal University of Goias
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Abstract:

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HsDHODH, SARS-CoV-2, Host-directed antiviral, Virtual screening, Structure-based drug design, Computational drug discovery