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Caroline S. Freitas

Fundação Oswaldo Cruz - Instituto Oswaldo Cruz

SCHOLARLY PAPERS

2

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76

TOTAL CITATIONS

0

Scholarly Papers (2)

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1.

Targeting Dihydroorotate Dehydrogenase (Dhodh) for Host-Directed Therapy: Discovery of a Novel Alkyne-Based Scaffold Inhibitor Effective Against Sars-Cov-2

Number of pages: 64 Posted: 28 Jan 2025
Flavio da Silva Emery, Miguel M. Vaidergorn, Aline D. Purificação, Pedro I. P. Leite, Sabrina Silva-Mendonça, Wemenes J. L. Silva, Thiago dos Santos, Daniel Gedder Silva, Bruna Fleck Godoi, Carolina Sacramento, Mayara Mattos, Natalia Fintelman-Rodrigues, Caroline S. Freitas, Luis Damasceno, Yoko Shishikura, Alex Brown, Karolina Wrobel, Jennifer Riley, Thiago Souza, Kevin D. Read, Jose Alves-filho, Carolina H. Andrade and Maria Cristina Nonato
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Federal University of Goias, Federal University of Goias, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Oswaldo Cruz Foundation (FIOCRUZ), Fundação Oswaldo Cruz - Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (FIOCRUZ), Fundação Oswaldo Cruz - Instituto Oswaldo Cruz, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Oswaldo Cruz Foundation (FIOCRUZ), affiliation not provided to SSRN, University of São Paulo (USP), Federal University of Goias and affiliation not provided to SSRN
Downloads 60 (961,006)

Abstract:

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Dihydroorotate dehydrogenase, fragments, antiviral, host-directed therapy, diarylethines

2.

Targeting HsDHODH for Host-Directed Therapy: Shape and Machine-learning Guided Discovery and Structural Validation of SARS-CoV-2 Antivirals​

Number of pages: 54 Posted: 20 May 2026
Luiza Vieira da Cruz, Sabrina Silva-Mendonça, Aline D. Purificação, Melina Mottin, Miguel Arbeláez, Caroline S. Freitas, Natalia Fintelman-Rodrigues, Mayara Mattos, Thamires Quadros Froes, Christopher Jurisch, Donald Seanego, Grant Boyle, Fernanda de França Genuíno Ramos Campos, Thiago Souza, Richard Gessner, Kelly Chibale, Maria Cristina Nonato and Carolina H. Andrade
affiliation not provided to SSRN, Federal University of Goias, affiliation not provided to SSRN, affiliation not provided to SSRN, Universidad Nacional de Colombia, Fundação Oswaldo Cruz - Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (FIOCRUZ), Fundação Oswaldo Cruz - Instituto Oswaldo Cruz, State University of Feira de Santana, University of Cape Town, University of Cape Town, University of Cape Town, affiliation not provided to SSRN, Oswaldo Cruz Foundation (FIOCRUZ), University of Cape Town, University of Cape Town, affiliation not provided to SSRN and Federal University of Goias
Downloads 16 (1,509,872)

Abstract:

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HsDHODH, SARS-CoV-2, Host-directed antiviral, Virtual screening, Structure-based drug design, Computational drug discovery