default author photo

Takahiro Seki

affiliation not provided to SSRN

  • affiliation not provided to SSRN

SCHOLARLY PAPERS

1

DOWNLOADS

152

TOTAL CITATIONS

0

Scholarly Papers (1)

Actions:
Email selected abstracts
1.

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Downloads 152

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 14 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 25

Abstract:

Loading...

Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 21 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 24

Abstract:

Loading...

Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 11 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 21

Abstract:

Loading...

Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 09 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 17

Abstract:

Loading...

Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 13 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 17

Abstract:

Loading...

Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 10 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 16

Abstract:

Loading...

Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 13 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 16

Abstract:

Loading...

Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 24 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 16

Abstract:

Loading...

Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity