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Taishi Higashi

Kumamoto University

SCHOLARLY PAPERS

3

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Scholarly Papers (3)

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1.

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

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A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 14 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 21 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 11 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 09 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 13 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 13 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 24 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

A preclinical study evaluating how degrees of substitution beyond the pharmacopeial range of 2-hydroxypropyl-β-cyclodextrin affect therapeutic efficacy and auditory function after intracerebroventricular administration for Niemann–Pick disease type C

Number of pages: 22 Posted: 10 Jun 2026
Mayuko Tanaka, Hazuki Nakagawa, Yusei Yamada, Kazuki Nakazono, Yuki Kondo, Kazunori Yanagihara, Kandai Ishikura, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
Kumamoto University, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-pick disease type C, 2-hydroxypropyl-β-cyclodextrin, degrees of substitution, intracerebroventricular administration, ototoxicity

2.

Fine-Tuned Cholesterol Solubilizer, Mono-6-O-α-D-Maltosyl-γ-Cyclodextrin, Ameliorates Experimental Niemann–Pick Disease Type C Without Hearing Loss

Number of pages: 29 Posted: 17 Feb 2022
Yusei Yamada, Toru Miwa, Masaki Nakashima, Aina Shirakawa, Nanami Namba, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Yasuyo Okada, Atsushi Ichikawa, Katsumi Higaki, Ken Hayashi, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Yoshihide Ishikawa, Tomohito Kajii, Kyoko Tachii, Hiroki Takeda, Yorihisa Orita, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
University of Miyazaki Hospital, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, Daiichi University of Pharmacy, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Tottori University, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Miyazaki Hospital, University of Miyazaki Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
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Niemann-Pick disease type C, Cyclodextrin, Cholesterol, Solubilization, Ototoxicity, Physicochemical property

3.

2-Hydroxypropyl-Β-Cyclodextrin with a High Degree of Substitution Has Higher Ability to Solubilize Cholesterol But a Weaker Therapeutic Effect on Niemann–Pick Disease Type C

Number of pages: 21 Posted: 17 Jul 2025
Akira Ishii, Mayuko Tanaka, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, Katsumi Higaki, Tomoko Kondo, Kandai Ishikura, Kazunori Yanagihara, Yoshinori Nakagawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie and Yoichi Ishitsuka
affiliation not provided to SSRN, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, Daiichi University of Pharmacy, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences
Downloads 68 (907,769)

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Niemann-pick disease type C, cyclodextrin, cholesterol, stoichiometry, solubilizing ability, lysosomal storage disease