University of Miyazaki Hospital, The Tazuke Kofukai Medical Research Institute - Kitano Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, Daiichi University of Pharmacy, Kumamoto University, affiliation not provided to SSRN, Kumamoto University, affiliation not provided to SSRN, affiliation not provided to SSRN, Tottori University, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Miyazaki Hospital, University of Miyazaki Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Kumamoto University, Kumamoto University, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences