affiliation not provided to SSRN, Kumamoto University, University of Miyazaki Hospital, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, Kumamoto University, Daiichi University of Pharmacy, Kumamoto University, Kumamoto University, affiliation not provided to SSRN, Tottori University, Kagoshima University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Miyazaki Hospital, Saga University, Kumamoto University and Kumamoto University - Graduate School of Pharmaceutical Sciences