Japanese Foundation for Cancer Research - Project for Cellular Senescence, Japanese Foundation for Cancer Research - Project for Cellular Senescence, Japanese Foundation for Cancer Research - Project for Cellular Senescence, Japanese Foundation for Cancer Research - Project for Cellular Senescence, National Institute of Advanced Industrial Science and Technology (AIST) - Biomedical Research Institute, Kyushu University - 4Institute of Mathematics for Industry, Chiba University - Division of Diabetes, Metabolism and EndocrinologyChiba University - Department of Endocrinology, Hematology and Gerontology, Chiba University - Department of Endocrinology, Hematology and Gerontology, Kanazawa University - Division of Genetics, Kanazawa University - Division of Genetics, Osaka University - Laboratory of Genome Structure and Function, Osaka University - Laboratory of Genome Structure and Function, Japanese Foundation for Cancer Research - Department of Gastroenterological Surgery, National Center for Global Health and Medicine - Department of Stem Cell Biology, Tokyo Medical and Dental University (TMDU) - Department of Molecular Genetics, University of Miami - Department of Medicine, Japan Science and Technology Agency (JST) - Precursory Research for Embryonic Science and Technology (PRESTO), Osaka University - Department of Molecular Microbiology and Japanese Foundation for Cancer Research