The Chinese University of Hong Kong (CUHK) - Department of Medicine and Therapeutics, University of Oxford - Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, University of Oxford - Medical Research Council Population Health Research Unit (MRC PHRU), Chinese Academy of Medical Sciences, University of Edinburgh, Zhejiang University, Peking University Health Science Center - School of Public Health, The Chinese University of Hong Kong (CUHK), The Chinese University of Hong Kong (CUHK), University of Edinburgh, Chinese Academy of Medical Sciences, University of Oxford - Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) and University of Edinburgh - Usher Institute of Population Health Sciences and Informatics