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Adelbert Bacher

University of Hamburg

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Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Sub-Pocket of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (DXR)

Number of pages: 35 Posted: 14 Dec 2023
Mona A. Abdullaziz, Sana Takada, Boris Illarionov, Lais Pessanha de Carvalho, Yasumitsu Sakamoto, Stefan Höfmann, Talea Knak, Anna-Lene Kiffe-Delf, Flaminia Mazzone, Klaus Pfeffer, Rainer Kalscheuer, Adelbert Bacher, Jana Held, Markus Fischer, Nobutada Tanak and Thomas Kurz
Heinrich Heine University Dusseldorf, Kitasato University, University of Hamburg, Eberhard-Karls University Tübingen, Iwate Medical University, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, University of Hamburg, University of Tübingen, University of Hamburg, Kitasato University and Heinrich Heine University Dusseldorf
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Fosmidomycin, N-substituted hydroxamic acids, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR, IspC), non-mevalonate biosynthesis pathway, antiplasmodial activity, co crystal structures.