Radboud University Nijmegen - Radboud University Medical Center, University of Cambridge - MRC Biostatistics Unit, Netherlands Comprehensive Cancer Organisation, University of Birmingham, University of Birmingham - Institute of Applied Health Research, University of Sheffield, University of Toronto - University Health Network, Radboud University Nijmegen - Radboud University Medical Center, Universitat de Barcelona, Royal Marsden NHS Foundation Trust - Department of Oncology, Maastricht University, Radboud University Nijmegen - Radboud University Medical Center and Radboud University Nijmegen - Radboud University Medical Center