University of Toronto - University Health Network, Princess Margaret Hospital, University of Western Ontario, University of Manitoba, affiliation not provided to SSRN, Nanostics Inc, McGill University - McGill University Health Centre, affiliation not provided to SSRN, University of Montréal - Cancer Prognostics and Health Outcomes Unit, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Toronto, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Toronto - Princess Margaret Cancer Centre, affiliation not provided to SSRN, University of Toronto - University Health Network, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - University Health Network, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and The Kinghorn Cancer Centre

Radboud University Nijmegen - Radboud University Medical Center, University of Cambridge - MRC Biostatistics Unit, Netherlands Comprehensive Cancer Organisation, University of Birmingham, University of Birmingham - Institute of Applied Health Research, University of Sheffield, University of Toronto - University Health Network, Radboud University Nijmegen - Radboud University Medical Center, Universitat de Barcelona, Royal Marsden NHS Foundation Trust - Department of Oncology, Maastricht University, Radboud University Nijmegen - Radboud University Medical Center and Radboud University Nijmegen - Radboud University Medical Center