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Refugio Martinez

University of Washington - Department of Pathology

Seattle, WA 98115

United States

SCHOLARLY PAPERS

3

DOWNLOADS

106

TOTAL CITATIONS

1

Scholarly Papers (3)

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1.

Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

Number of pages: 29 Posted: 23 Jan 2020
Allison Knupp, Swati Mishra, Refugio Martinez, Jacquelyn E. Braggin, Marcell Szabo, Dale W. Hailey, Scott A. Small, Suman Jayadev and Jessica E. Young
University of Washington - Department of Pathology, University of Washington - Department of Pathology, University of Washington - Department of Pathology, University of Washington - Department of Neurology, University of Washington - Department of Pathology, University of Washington - Institute for Stem Cell and Regenerative Medicine, Columbia University - Taub Institute for Research on Alzheimer's and the Aging Brain, University of Washington - Department of Neurology and University of Washington - Department of Pathology
Downloads 49 (1,086,013)

Abstract:

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Alzheimer's Disease, human induced pluripotent stem cells, SORL1, early endosomes

2.

Functional Enhancer Elements Drive Subclass-Selective Expression from Mouse to Primate Neocortex

Number of pages: 93 Posted: 20 May 2020
John K. Mich, Lucas T. Graybuck, Erik Hess, Joseph Mahoney, Yoshiko Kojima, Yi Ding, Saroja Somasundaram, Jeremy A. Miller, Natalie Weed, Victoria Omstead, Yemeserach Bishaw, Nadiya Shapovalova, Refugio Martinez, Olivia Fong, Shenqin Yao, Marty Mortrud, Peter Chong, Luke Loftus, Darren Bertagnolli, Jeff Goldy, Tamara Casper, Nick Dee, Ximena Opitz-Araya, Ali Cetin, Kimberly A. Smith, Ryder P. Gwinn, Charles Cobbs, Andrew L. Ko, Jeffrey G. Ojemann, C. Dirk Keene, Daniel L. Silbergeld, Susan M. Sunkin, Viviana Gradinaru, Gregory D. Horwitz, Hongkui Zeng, Bosiljka Tasic, Ed Lein, Jonathan Ting and Boaz Levi
Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, University of Washington - Washington National Primate Research Center, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, University of Washington - Department of Pathology, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Stanford University - Department of Biology, Allen Institute - Allen Institute for Brain Science, Swedish Neuroscience Institute - Department of Epilepsy Surgery and Functional Neurosurgery, Swedish Neuroscience Institute - The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, University of Washington - Department of Neurological Surgery, Seattle Children's Hospital, University of Washington - Department of Pathology, University of Washington - Department of Neurological Surgery, Allen Institute - Allen Institute for Brain Science, California Institute of Technology (Caltech) - Division of Biology and Biological Engineering, University of Washington - Washington National Primate Research Center, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science and Allen Institute - Allen Institute for Brain Science
Downloads 45 (1,133,231)
Citation 1

Abstract:

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Human, macaque, brain cell types, epigenetics, enhancers, AAVs, neocortex, reporters, genetic tools, ex vivo brain slice, ATAC-seq, RNA-seq, Parvalbumin

3.

Enhancer-Based AAV Approach for Selective AADC Delivery Reduces Motor Symptoms and Dyskinesia in Parkinson’s Mouse Models

Number of pages: 78 Posted: 17 Feb 2026
Ananya Chowdhury, Alex Fraser, Max Departee, Naz Taskin, Meagan A. Quinlan, John K. Mich, Victoria Omstead, Nathaly Lerma, Ximena Opitz-Araya, Alex C. Hughes, Emily Kussick, Refugio Martinez, Melissa Reding, Elizabeth Liang, Lyudmila Shulga, Dean Rette, Cindy Huang, Brittny Casian, Madison Leibly, Olivia Helback, Tyler Barcelli, Toren Wood, Nicholas Uribe, Colin Bacon, Jessica Bowlus, Dakota Newman, Rana Kutsal, Shannon Khem, Nicholas Donadio, Shenqin Yao, Kara Ronellenfitch, Vonn Wright, Kathryn Gudsnuk, Greg D. Horwitz, Boaz Levi, Ed S. Lein, Jonathan T. Ting and Tanya Daigle
Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute - Allen Institute for Brain Science, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, University of Washington - Department of Pathology, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, Allen Institute, University of Washington, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science, Allen Institute - Allen Institute for Brain Science and Allen Institute
Downloads 12 (1,548,648)

Abstract:

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AAV, AADC, neurodegeneration, Parkinson's disease, therapy, L-DOPA, striatum, dopamine, nigrostriatal, motor behaviors, locus coeruleus