University of Genova - Section of Biostatistics, University of Genova - Department of Health Sciences, University of Genova - Section of Biostatistics, Centro Sclerosi Multipla ASST Spedali Civili di Brescia, Università Vita-Salute San Raffaele, ASST Papa Giovanni XXIII - Department of Neurology and Multiple Sclerosis Center, Ospedale Guglielmo da Saliceto - Multiple Sclerosis Center, San Luigi Gonzaga University Hospital, ASST-Spedali Civili of Brescia, Italian MS Foundation, Universita di Cagliari, IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), City of Health and Science University Hospital of Turin - Department of Neuroscience - MS Center, Centro SM UOC Neurologia, Fidenza, AUSL PR, University of Pavia, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Rome Tor Vergata, University of Padua, IRCCS Ospedale Policlinico San Martino, Università degli Studi di Bari “Aldo Moro” (UNIBA), University of Naples Federico II, University of Campania Federico II, Università Vita-Salute San Raffaele, University of Siena - Department of Life Sciences, University of Catania, Sapienza University of Rome - Department of Neuroscience, Mental Health and Sensory Organs, Center for Experimental Neurological Therapies (CENTERS) and Independent

KU Leuven - ESAT-STADIUS, Hasselt University, Ghent University, Ghent University, Ghent University, affiliation not provided to SSRN, Ghent University, affiliation not provided to SSRN, affiliation not provided to SSRN, Ghent University, Ghent University, Ghent University, Ghent University, Ghent University, Charles University and General University Hospital - Department of Neurology and Center of Clinical Neuroscience, University of Catania, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Montreal, University of Montreal - Neuroimmunology Research Laboratory, University of Bologna, affiliation not provided to SSRN, University of Melbourne - CORe, affiliation not provided to SSRN, affiliation not provided to SSRN, Box Hill Hospital, 19 Mayis University, affiliation not provided to SSRN, Zuyderland Medical Centre, American University of Beirut, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, State University of New York (SUNY) - Department of Neurology, Universitat de Barcelona, affiliation not provided to SSRN, affiliation not provided to SSRN, Ente Ospedaliero Ospedali Galliera, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Guilan University of Medical Sciences - Razi Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, Monash University - Department of Neuroscience, affiliation not provided to SSRN, Reina Sofia University Hospital, Koç University, Sultan Qaboos University, Groene Hart Ziekenhuis, affiliation not provided to SSRN, University of Debrecen, South Western Sydney Local Health District - Liverpool Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, Royal Hobart Hospital, affiliation not provided to SSRN, University of Geneva - Geneva University Hospitals, affiliation not provided to SSRN, affiliation not provided to SSRN, Perron Institute for Neurological and Translational Science, Hospital General Universitario de Alicante, affiliation not provided to SSRN, Semmelweis University, The University of Sydney - Concord Repatriation General Hospital, affiliation not provided to SSRN, Royal Victoria Hospital, Department of Neurology, Aristotle University of Thessaloniki, affiliation not provided to SSRN, Mater Dei Hospital, KU Leuven - ESAT-STADIUS and Hasselt University - Data Science Institute