University of Genova - Section of Biostatistics, IRCCS Ospedale Policlinico San Martino, University of Genova - Department of Health Sciences, University of Genova - Section of Biostatistics, University of Genoa - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), IRCCS Ospedale Policlinico San Martino, IRCCS Ospedale Policlinico San Martino - Laboratory Medicine, Imperia Hospital - Department of Neurology, Galliera Hospital - Neurology Unit, Ospedale Santa Corona Pietra Ligure (Sv) - S.C. Neurologia, SC Neurologia ASL 4 Chiavarese, Italian MS Foundation, Centro Sclerosi Multipla S.C. Neurologia Asl 3 Genovese, Sant’Andrea Hospital - Department of Neurology, Università degli Studi di Siena - Clinica Neurologica e Malattie Neurometaboliche, Centro Sclerosi Multipla ASST Spedali Civili di Brescia, Tor Vergata University and Hospital - Multiple Sclerosis Clinical and Research Unit, Università di Torino - Dipartimento di Scienze Cliniche e Biologiche, Università della Campania Luigi Vanvitelli - Centro Sclerosi Multipla, Università di Cagliari - Centro Sclerosi Multipla Ospedale Binaghi Cagliari - ATS Sardegna, ASST Crema - Neuroimmunology, Regina Montis Regalis Hospital - Department of Neurology, University of Pisa - Neurology Unit, University of Siena - Department of Medicine, Surgery and Neuroscience, Fabrizio Spaziani Hospital - Multiple Sclerosis Center, UOC Neurologia e Centro SM Fondazione Istituto G. Giglio, Università Federico II di Napopi - Clinica Neurologica, IRCCS Humanitas Research Hospital - Neuromuscular and Neuroimmunology Service, F. Tappeiner Hospital Meran (BZ) - MS Center, Careggi University Hospital - Department of Neurology 2, Ospedale Regionale - Department of Neurology, University of Siena - Department of Life Sciences, Sapienza University of Rome - Department of Neuroscience, Mental Health and Sensory Organs, Center for Experimental Neurological Therapies (CENTERS), IRCCS Ospedale Policlinico San Martino - Autoimmunology Laboratory, Università degli Studi di Genova - Center of Excellence for Biomedical Research (CEBR) and Independent

University of Genoa, University of Genova - Section of Biostatistics, University of Genoa, University of Genova - Section of Biostatistics, University of Genova - Department of Health Sciences, University of Genova - Section of Biostatistics, Autonomous University of Barcelona, University of Basel - Neurologic Clinic and Policlinic, Basel University, McGill University, Basel University and University of Genova - Section of Biostatistics

University of Genova - Section of Biostatistics, University of Genova - Department of Health Sciences, University of Genova - Section of Biostatistics, Centro Sclerosi Multipla ASST Spedali Civili di Brescia, Università Vita-Salute San Raffaele, ASST Papa Giovanni XXIII - Department of Neurology and Multiple Sclerosis Center, Ospedale Guglielmo da Saliceto - Multiple Sclerosis Center, San Luigi Gonzaga University Hospital, ASST-Spedali Civili of Brescia, Italian MS Foundation, Universita di Cagliari, IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), City of Health and Science University Hospital of Turin - Department of Neuroscience - MS Center, Centro SM UOC Neurologia, Fidenza, AUSL PR, University of Pavia, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Rome Tor Vergata, University of Padua, IRCCS Ospedale Policlinico San Martino, Università degli Studi di Bari “Aldo Moro” (UNIBA), University of Naples Federico II, University of Campania Federico II, Università Vita-Salute San Raffaele, University of Siena - Department of Life Sciences, University of Catania, Sapienza University of Rome - Department of Neuroscience, Mental Health and Sensory Organs, Center for Experimental Neurological Therapies (CENTERS) and Independent

Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Ospedale Policlinico San Martino, University of Genova - Section of Biostatistics, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Ospedale Policlinico San Martino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Ospedale Policlinico San Martino, affiliation not provided to SSRN, affiliation not provided to SSRN, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Ospedale Policlinico San Martino, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN