University of Genoa, University of Genova - Section of Biostatistics, University of Genoa, University of Genova - Section of Biostatistics, University of Genova - Department of Health Sciences, University of Genova - Section of Biostatistics, Autonomous University of Barcelona, University of Basel - Neurologic Clinic and Policlinic, Basel University, McGill University, Basel University and University of Genova - Section of Biostatistics