University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee - Division of Molecular and Clinical Medicine, University of Barcelona - Respiratory Department, University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee, University Hospital of Bellvitge - Respiratory Department, University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee - Division of Molecular and Clinical Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Dundee - Division of Molecular and Clinical Medicine, Queen's University Belfast - Centre for Experimental Medicine, University of Dundee - Division of Molecular and Clinical Medicine, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee - Division of Molecular and Clinical Medicine, South Australian Health and Medical Research Institute - Microbime & Host Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Barcelona - Respiratory Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Newcastle (Australia) - Priority Research Centre for Healthy Lungs, University of Dundee - Division of Systems Medicine and University of Dundee - Division of Molecular and Clinical Medicine