University of Dundee - Division of Molecular and Clinical Medicine, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, University of Dundee - Division of Molecular and Clinical Medicine, Hannover Medical School - Department of Respiratory Medicine, Newcastle University - Population Health Sciences Institute, Dr Trueta University Hospita - Bronchiectasis Research Group, Assistance Publique-Hopitaux de Paris (AP-HP) - Assistance Publique-Hôpitaux de Paris, NHS Foundation Trust - Cambridge Centre for Lung Infection, Government of the United Kingdom - Royal Brompton Hospital, Sotiria General Hospital of Chest Diseases of Athens, Université de Toulouse - Department of Respiratory Diseases, Government of the United Kingdom - Royal Brompton Hospital, Royal Infirmary of Edinburgh, Hospital Universitario y Politecnico La Fe, University of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Pneumology, Hannover Medical School, member of the German Centre for Lung Research (DZL), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Amsterdam - University Medical Center, Carmel Medical Center - Pulmonology Institute and CF Center, Northwest Clinics - Department of Pulmonary Diseases, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, AZ Nikolaas - Department of Respiratory Disease, IRCCS Humanitas Research Hospital and Independent

University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee - Division of Molecular and Clinical Medicine, University of Barcelona - Respiratory Department, University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee, University Hospital of Bellvitge - Respiratory Department, University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee - Division of Molecular and Clinical Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Dundee - Division of Molecular and Clinical Medicine, Queen's University Belfast - Centre for Experimental Medicine, University of Dundee - Division of Molecular and Clinical Medicine, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, University of Dundee - Division of Molecular and Clinical Medicine, University of Dundee - Division of Molecular and Clinical Medicine, South Australian Health and Medical Research Institute - Microbime & Host Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Barcelona - Respiratory Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Newcastle (Australia) - Priority Research Centre for Healthy Lungs, University of Dundee - Division of Systems Medicine and University of Dundee - Division of Molecular and Clinical Medicine

University of Duisburg-Essen - Division of Cystic Fibrosis, Ionis Pharmaceuticals, Ionis Pharmaceuticals, The University of Manchester - Wythenshawe Hospital, Ionis Pharmaceuticals, Ionis Pharmaceuticals, Ionis Pharmaceuticals, Ionis Pharmaceuticals and Queen’s University Belfast - Department of Medicine, Health and Life Sciences

University of Galway, Queen's University Belfast - Centre for Experimental Medicine, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, Queens University Belfast - School of Pharmacy, affiliation not provided to SSRN, Belfast Health and Social Care Trust, University of Edinburgh, Government of the United Kingdom - Royal Brompton Hospital, University of Southampton - University Hospital Southampton NHS Foundation Trust, affiliation not provided to SSRN, Newcastle University - Population Health Sciences Institute, University of Dundee - Division of Molecular and Clinical Medicine, NHS Foundation Trust - Royal Papworth Hospital, University College London, University College London, affiliation not provided to SSRN and Queen's University Belfast