University of Galway, Queen's University Belfast - Centre for Experimental Medicine, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, Queens University Belfast - School of Pharmacy, affiliation not provided to SSRN, Belfast Health and Social Care Trust, University of Edinburgh, Government of the United Kingdom - Royal Brompton Hospital, University of Southampton - University Hospital Southampton NHS Foundation Trust, affiliation not provided to SSRN, Newcastle University - Population Health Sciences Institute, University of Dundee - Division of Molecular and Clinical Medicine, NHS Foundation Trust - Royal Papworth Hospital, University College London, University College London, affiliation not provided to SSRN and Queen's University Belfast