University of Dundee, University of Dundee, University of Dundee, AstraZeneca Pharmaceuticals - UK, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee - Division of Systems Medicine, University of Dundee, Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Dundee, University of Dundee, University of Dundee, Hallym University, Newcastle University - Population Health Sciences Institute, King’s College London, Hannover Medical School - Department of Respiratory Medicine, University Hospitals Leuven - Department of Pneumology, Imperial College London, Imperial College London, University of Dundee, AZ Nikolaas - Department of Respiratory Disease, Government of the United Kingdom - Royal Brompton Hospital, Zhengzhou University, Nanyang Technological University (NTU), The Calcutta Medical Research Institute, NHS Foundation Trust - Cambridge Centre for Lung Infection, University of Amsterdam - University Medical Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, Carmel Medical Center - Pulmonology Institute and CF Center, AstraZeneca Pharmaceuticals - UK, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Imperial College London, IRCCS Humanitas Research Hospital, University of Barcelona, University of Dundee and University of Dundee - Division of Molecular and Clinical Medicine

University of Dundee - Division of Molecular and Clinical Medicine, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, University of Dundee - Division of Molecular and Clinical Medicine, Hannover Medical School - Department of Respiratory Medicine, Newcastle University - Population Health Sciences Institute, Dr Trueta University Hospita - Bronchiectasis Research Group, Assistance Publique-Hopitaux de Paris (AP-HP) - Assistance Publique-Hôpitaux de Paris, NHS Foundation Trust - Cambridge Centre for Lung Infection, Government of the United Kingdom - Royal Brompton Hospital, Sotiria General Hospital of Chest Diseases of Athens, Université de Toulouse - Department of Respiratory Diseases, Government of the United Kingdom - Royal Brompton Hospital, Royal Infirmary of Edinburgh, Hospital Universitario y Politecnico La Fe, University of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Pneumology, Hannover Medical School, member of the German Centre for Lung Research (DZL), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Amsterdam - University Medical Center, Carmel Medical Center - Pulmonology Institute and CF Center, Northwest Clinics - Department of Pulmonary Diseases, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, AZ Nikolaas - Department of Respiratory Disease, IRCCS Humanitas Research Hospital and Independent

University of Galway, Queen's University Belfast - Centre for Experimental Medicine, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, Queens University Belfast - School of Pharmacy, affiliation not provided to SSRN, Belfast Health and Social Care Trust, University of Edinburgh, Government of the United Kingdom - Royal Brompton Hospital, University of Southampton - University Hospital Southampton NHS Foundation Trust, affiliation not provided to SSRN, Newcastle University - Population Health Sciences Institute, University of Dundee - Division of Molecular and Clinical Medicine, NHS Foundation Trust - Royal Papworth Hospital, University College London, University College London, affiliation not provided to SSRN and Queen's University Belfast