University of Dundee, University of Dundee, University of Dundee, AstraZeneca Pharmaceuticals - UK, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee - Division of Systems Medicine, University of Dundee, Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Dundee, University of Dundee, University of Dundee, Hallym University, Newcastle University - Population Health Sciences Institute, King’s College London, Hannover Medical School - Department of Respiratory Medicine, University Hospitals Leuven - Department of Pneumology, Imperial College London, Imperial College London, University of Dundee, AZ Nikolaas - Department of Respiratory Disease, Government of the United Kingdom - Royal Brompton Hospital, Zhengzhou University, Nanyang Technological University (NTU), The Calcutta Medical Research Institute, NHS Foundation Trust - Cambridge Centre for Lung Infection, University of Amsterdam - University Medical Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, Carmel Medical Center - Pulmonology Institute and CF Center, AstraZeneca Pharmaceuticals - UK, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Imperial College London, IRCCS Humanitas Research Hospital, University of Barcelona, University of Dundee and University of Dundee - Division of Molecular and Clinical Medicine

University of Cambridge, University of Cambridge, University of Cambridge, University of Cambridge, Department of Medicine, University of Cambridge, Bristol Adult Cystic Fibrosis Centre, University Hospitals Bristol NHS Foundation Trust, Imperial College London - National Heart and Lung Institute, Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Adult Cystic Fibrosis Department, King’s College Hospital, NHS Foundation Trust - Cambridge Centre for Lung Infection, Adult Cystic Fibrosis Centre, Royal Brompton Hospital, Frimley Park Hospital, Leeds Regional Adult Cystic Fibrosis Centre, St James's University Hospital, Microsoft Corporation - Machine Intelligence Group, University of Cambridge - Molecular Immunity Unit, Leeds Regional Adult Cystic Fibrosis Centre, St James's University Hospital, Leeds Regional Adult Cystic Fibrosis Centre, St James's University Hospital, Adult Cystic Fibrosis Department, King’s College Hospital, Bristol Adult Cystic Fibrosis Centre, University Hospitals Bristol NHS Foundation Trust, Bristol Adult Cystic Fibrosis Centre, University Hospitals Bristol NHS Foundation Trust, Bristol Adult Cystic Fibrosis Centre, University Hospitals Bristol NHS Foundation Trust and Cambridge Centre for Lung Infection, Royal Papworth Hospital

University of Dundee - Division of Molecular and Clinical Medicine, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, University of Dundee - Division of Molecular and Clinical Medicine, Hannover Medical School - Department of Respiratory Medicine, Newcastle University - Population Health Sciences Institute, Dr Trueta University Hospita - Bronchiectasis Research Group, Assistance Publique-Hopitaux de Paris (AP-HP) - Assistance Publique-Hôpitaux de Paris, NHS Foundation Trust - Cambridge Centre for Lung Infection, Government of the United Kingdom - Royal Brompton Hospital, Sotiria General Hospital of Chest Diseases of Athens, Université de Toulouse - Department of Respiratory Diseases, Government of the United Kingdom - Royal Brompton Hospital, Royal Infirmary of Edinburgh, Hospital Universitario y Politecnico La Fe, University of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Pneumology, Hannover Medical School, member of the German Centre for Lung Research (DZL), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Amsterdam - University Medical Center, Carmel Medical Center - Pulmonology Institute and CF Center, Northwest Clinics - Department of Pulmonary Diseases, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, AZ Nikolaas - Department of Respiratory Disease, IRCCS Humanitas Research Hospital and Independent

University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, Queen's University Belfast, University of Dundee, University of Dundee, University of Dundee - Division of Systems Medicine, NHS Foundation Trust - Cambridge Centre for Lung Infection and University of Dundee - Division of Molecular and Clinical Medicine

NHS Foundation Trust - Cambridge Centre for Lung Infection, Imperial College London - National Heart and Lung Institute, University of Dundee, Grifols Inc., Aradigm Corporation, Aradigm Corporation, Theta Hat Statistical Consultants LLC, University of Miami and Georgetown University

University of Dundee, affiliation not provided to SSRN, Hannover Medical School - Department of Respiratory Medicine, Government of the United Kingdom - Royal Brompton Hospital, Lung Foundation Australia, Bronchiectasis and NTM Association, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, Hannover Medical School, University of Dundee, University of Dundee, University of New South Wales, University of Dundee, University of Dundee, Newcastle University - Population Health Sciences Institute, Dr Trueta University Hospita - Bronchiectasis Research Group, Assistance Publique-Hopitaux de Paris (AP-HP) - Assistance Publique-Hôpitaux de Paris, NHS Foundation Trust - Cambridge Centre for Lung Infection, Sotiria General Hospital of Chest Diseases of Athens, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Amsterdam - University Medical Center, Carmel Medical Center - Pulmonology Institute and CF Center, AZ Nikolaas - Department of Respiratory Disease, The Calcutta Medical Research Institute, University of Alberta, University of Calgary, IRCCS Humanitas Research Hospital, University of Calgary, University of Queensland - Faculty of Medicine, The University of Sydney - Concord Hospital, University of Connecticut - Center for Bronchiectasis Care Pulmonary, Critical Care and Sleep Medicine and University of Dundee - Division of Molecular and Clinical Medicine