University of Dundee, University of Dundee, University of Dundee, AstraZeneca Pharmaceuticals - UK, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee - Division of Systems Medicine, University of Dundee, Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Dundee, University of Dundee, University of Dundee, Hallym University, Newcastle University - Population Health Sciences Institute, King’s College London, Hannover Medical School - Department of Respiratory Medicine, University Hospitals Leuven - Department of Pneumology, Imperial College London, Imperial College London, University of Dundee, AZ Nikolaas - Department of Respiratory Disease, Government of the United Kingdom - Royal Brompton Hospital, Zhengzhou University, Nanyang Technological University (NTU), The Calcutta Medical Research Institute, NHS Foundation Trust - Cambridge Centre for Lung Infection, University of Amsterdam - University Medical Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, Carmel Medical Center - Pulmonology Institute and CF Center, AstraZeneca Pharmaceuticals - UK, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Insmed Incorporated, Imperial College London, IRCCS Humanitas Research Hospital, University of Barcelona, University of Dundee and University of Dundee - Division of Molecular and Clinical Medicine

University of Dundee - Division of Molecular and Clinical Medicine, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, University of Dundee - Division of Molecular and Clinical Medicine, Hannover Medical School - Department of Respiratory Medicine, Newcastle University - Population Health Sciences Institute, Dr Trueta University Hospita - Bronchiectasis Research Group, Assistance Publique-Hopitaux de Paris (AP-HP) - Assistance Publique-Hôpitaux de Paris, NHS Foundation Trust - Cambridge Centre for Lung Infection, Government of the United Kingdom - Royal Brompton Hospital, Sotiria General Hospital of Chest Diseases of Athens, Université de Toulouse - Department of Respiratory Diseases, Government of the United Kingdom - Royal Brompton Hospital, Royal Infirmary of Edinburgh, Hospital Universitario y Politecnico La Fe, University of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Pneumology, Hannover Medical School, member of the German Centre for Lung Research (DZL), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Amsterdam - University Medical Center, Carmel Medical Center - Pulmonology Institute and CF Center, Northwest Clinics - Department of Pulmonary Diseases, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, AZ Nikolaas - Department of Respiratory Disease, IRCCS Humanitas Research Hospital and Independent

University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Dundee, University of Leicester - Department of Health Sciences, University of Leicester - Institute for Lung Health, University of Leicester - Institute for Lung Health, University of Leicester - Institute for Lung Health, University Hospitals of Leicester NHS Trust, University of Leicester - Institute for Lung Health, University of Leicester - Institute for Lung Health, University of Leicester - Institute for Lung Health, University of Leicester - Institute for Lung Health, University of Leicester - Centre for Exercise and Rehabilitation Science, University of Leicester - Institute for Lung Health, University of Leicester, University of Leicester, University of Leicester, University of Edinburgh - Centre for Medical Informatics, University of Edinburgh - Centre for Medical Informatics, University of Edinburgh - Usher Institute, University of Edinburgh - Asthma UK Centre for Applied Research, Imperial College London - National Heart and Lung Institute, University of Edinburgh - Usher Institute, University of Edinburgh, London School of Hygiene & Tropical Medicine, Imperial College London, University of Oxford, Imperial College London - National Heart and Lung Institute, King's College London - Institute of Psychiatry, Psychology & Neuroscience, University of Leicester - Leicester Diabetes Centre, Newcastle University - Population Health Sciences Institute, University of Oxford, University of Liverpool, Imperial College London - Hammersmith Hospital, University College London, Imperial College London - National Heart and Lung Institute, University Hospitals of Leicester NHS Trust, University of Leicester - NIHR Leicester Biomedical Research Centre, University of Oxford - Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Imperial College London - National Heart and Lung Institute (NHLI), University College London - Centre for inflammation and Tissue Repair, Queen's University Belfast, University of Cambridge, Royal Papworth HospitalUniversity of Cambridge - Heart and Lung Research Institute, University of Sheffield, MRC-University of Glasgow Centre for Virus Research, University of Liverpool - Health Protection Research Unit in Emerging and Zoonotic Infections, University of Leicester - Centre for Exercise and Rehabilitation Science, NHS Foundation Trust - St. Georges University Hospitals, Leeds Teaching Hospitals NHS Trust, University of Nottingham, University College London, University of Edinburgh, The University of Manchester, Infection Research Group, Hull University Teaching Hospitals NHS Foundation Trust, Newcastle University, University of Cambridge, Guy's and St Thomas' NHS Foundation Trust, University College London, School of Life and Medical Sciences, Faculty of Medical Sciences, Division of Medicine, UCL Respiratory, University of Southampton - Department of Clinical and Experimental Sciences, University of Birmingham, Queen Mary University of London - Institute of Population Health Sciences, University of Oxford, University of Sheffield, King’s College London, Liverpool University Hospitals NHS Foundation Trust, Swansea University - College of Human and Health Sciences, Queen's University Belfast, Government of the United Kingdom - Oxford Interstitial Lung Disease Service, The University of Manchester - Wythenshawe Hospital, London School of Hygiene & Tropical Medicine - Department of Clinical Research, Asthma and Lung UK, University of Oxford - Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Leicester - Department of Health Sciences, University of Leicester - Institute for Lung Health, University of Leicester - Institute for Lung Health, Imperial College London - National Heart and Lung Institute and University of Dundee - Division of Molecular and Clinical Medicine

University of Galway, Queen's University Belfast - Centre for Experimental Medicine, Queen’s University Belfast - Department of Medicine, Health and Life Sciences, Queens University Belfast - School of Pharmacy, affiliation not provided to SSRN, Belfast Health and Social Care Trust, University of Edinburgh, Government of the United Kingdom - Royal Brompton Hospital, University of Southampton - University Hospital Southampton NHS Foundation Trust, affiliation not provided to SSRN, Newcastle University - Population Health Sciences Institute, University of Dundee - Division of Molecular and Clinical Medicine, NHS Foundation Trust - Royal Papworth Hospital, University College London, University College London, affiliation not provided to SSRN and Queen's University Belfast

University of Dundee, affiliation not provided to SSRN, Hannover Medical School - Department of Respiratory Medicine, Government of the United Kingdom - Royal Brompton Hospital, Lung Foundation Australia, Bronchiectasis and NTM Association, Hospital Universitari Vall d'Hebron of Barcelona - Pneumology Department, Hannover Medical School, University of Dundee, University of Dundee, University of New South Wales, University of Dundee, University of Dundee, Newcastle University - Population Health Sciences Institute, Dr Trueta University Hospita - Bronchiectasis Research Group, Assistance Publique-Hopitaux de Paris (AP-HP) - Assistance Publique-Hôpitaux de Paris, NHS Foundation Trust - Cambridge Centre for Lung Infection, Sotiria General Hospital of Chest Diseases of Athens, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Respiratory Unit and Cystic Fibrosis Adult Center, University of Amsterdam - University Medical Center, Carmel Medical Center - Pulmonology Institute and CF Center, AZ Nikolaas - Department of Respiratory Disease, The Calcutta Medical Research Institute, University of Alberta, University of Calgary, IRCCS Humanitas Research Hospital, University of Calgary, University of Queensland - Faculty of Medicine, The University of Sydney - Concord Hospital, University of Connecticut - Center for Bronchiectasis Care Pulmonary, Critical Care and Sleep Medicine and University of Dundee - Division of Molecular and Clinical Medicine