University of Birmingham - Institute of Immunology and Immunotherapy, University of Limerick - Health Research Institute and the Bernal Institute, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Warwick - Division of Biomedical Sciences, University of Warwick - Bioinformatics Research Technology Platform, University of Warwick - Division of Biomedical Sciences, University of Birmingham - Institute of Immunology and Immunotherapy, Birmingham Women’s and Children’s NHS Foundation Trust, Government of the United Kingdom - Birmingham Women’s and Children’s NHS Foundation Trust, Government of the United Kingdom - Birmingham Women’s and Children’s NHS Foundation Trust, Heartlands Hospital, Government of the United Kingdom - Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham Women’s and Children’s NHS Foundation Trust - Paediatric Intensive Care Unit, Government of the United Kingdom - Birmingham Women’s and Children’s NHS Foundation Trust, Government of the United Kingdom - Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham Women’s and Children’s NHS Foundation Trust - Paediatric Intensive Care Unit, University Hospitals Birmingham NHS Foundation Trust - Heartlands Hospital, University of Birmingham, University of Birmingham - Clinical Immunology Service, University of Birmingham - NIHR Birmingham Biomedical Research Centre and Institute of Cancer and Genomic Sciences and University of Birmingham - Institute of Immunology and Immunotherapy