University College London - UCL Cancer Institute, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Leeds Teaching Hospitals NHS Trust, Government of the United Kingdom - Queen Elizabeth Hospital Birmingham, Leeds Teaching Hospitals NHS Trust, affiliation not provided to SSRN, University Hospitals Bristol - University Hospitals Bristol and Weston NHS Foundation Trust, University Hospitals Bristol - University Hospitals Bristol and Weston NHS Foundation Trust, Imperial College London - Hammersmith Hospital, Department of Cancer Medicine, affiliation not provided to SSRN, University of Edinburgh - Western General Hospital, Government of the United Kingdom - Weston Park Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, NHS Foundation Trust - Cambridge University Hospitals, Government of the United Kingdom - Queen Elizabeth Hospital Birmingham, Royal Free Hospital, Heidelberg University, University of Southampton, Royal Marsden NHS Foundation Trust, affiliation not provided to SSRN, The University of Manchester and University of Southampton

The Christie NHS Foundation Trust - Department of Medical Oncology, Clatterbridge Cancer Centre, Imperial College London - Hammersmith Hospital, Department of Cancer Medicine, Guy's & St. Thomas’ NHS Foundation Trust - Guy’s Cancer, University Hospitals Birmingham NHS Foundation Trust, University of Nottingham, University Hospitals Bristol - Bristol Haematology and Oncology Centre, Government of the United Kingdom - Royal Free London NHS Foundation Trust, Weston Park Cancer Centre, Government of the United Kingdom - Oxford University Hospitals NHS Foundation Trust, Leeds Teaching Hospitals NHS Trust, Hull University Teaching Hospitals NHS Trust, University of Southampton - University Hospital Southampton NHS Foundation Trust, Maidstone and Tunbridge Wells NHS Trust - Kent Oncology Centre, Government of the United Kingdom - Great Western Hospitals, University of Manchester - Manchester Clinical Trials Unit, University of Manchester - Manchester Clinical Trials Unit, Hampshire Hospitals NHS Foundation Trust, University of Manchester - Department of Health Economics, University College London - UCL Cancer Institute, The Christie NHS Foundation Trust - Department of Medical Oncology and Independent