University College London - UCL Cancer Institute, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Leeds Teaching Hospitals NHS Trust, Government of the United Kingdom - Queen Elizabeth Hospital Birmingham, Leeds Teaching Hospitals NHS Trust, affiliation not provided to SSRN, University Hospitals Bristol - University Hospitals Bristol and Weston NHS Foundation Trust, University Hospitals Bristol - University Hospitals Bristol and Weston NHS Foundation Trust, Imperial College London - Hammersmith Hospital, Department of Cancer Medicine, affiliation not provided to SSRN, University of Edinburgh - Western General Hospital, Government of the United Kingdom - Weston Park Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Birmingham, NHS Foundation Trust - Cambridge University Hospitals, Government of the United Kingdom - Queen Elizabeth Hospital Birmingham, Royal Free Hospital, Heidelberg University, University of Southampton, Royal Marsden NHS Foundation Trust, affiliation not provided to SSRN, The University of Manchester and University of Southampton