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Mariano J. Alvarez

DarwinHealth, Inc.

New York, NY

United States

  • DarwinHealth, Inc.

SCHOLARLY PAPERS

3

DOWNLOADS

116

TOTAL CITATIONS

1

Scholarly Papers (3)

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1.

An RNA-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment Resistant Malignancies

Number of pages: 55 Posted: 28 Mar 2022
Prabhjot S. Mundi, Filemon S. Dela Cruz, Adina Grunn, Daniel Diolaiti, Audrey Mauguen, Allison R. Rainey, Kristina C. Guillan, Armaan Siddiquee, Daoqi You, Ronald Realubit, Charles Karan, Michael V. Ortiz, Eugene F. Douglass, Melissa Accordino, Suzanne Mistretta, Frances Brogan, Jeffrey N. Bruce, Cristina I. Caescu, Richard Carvajal, Katherine Crew, Guarionex Decastro, Mark Heaney, Brian Henick, Dawn Hershman, June Hou, Fabio Iwamoto, Joseph Jurcic, Ravi P. Kiran, Michael Kluger, Teri Kreisl, Nicole Lamanna, Andrew Lassman, Emerson Lim, Gulam A. Manji, Guy McKhann, James McKiernan, Alfred I. Neugut, Kenneth Olive, Todd Rosenblat, Gary K. Schwartz, Catherine Shu, Michael Sisti, Ana Tergas, Reena Vattakalam, Mary Welch, Sven Wenske, Jason D. Wright, Hanina Hibshoosh, Kevin M. Kalinsky, Mahalaxmi Aburi, Peter A. Sims, Mariano J. Alvarez, Andrew L. Kung and Andrea Califano
Columbia University - Irving Medical Center, Memorial Sloan Kettering Cancer Center, Columbia University - Irving Medical Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Memorial Sloan Kettering Cancer Center, Columbia University - Department of Systems Biology, Columbia University - Herbert Irving Comprehensive Cancer Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Department of Medicine, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Department of Medicine, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Cambridge, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University, Columbia University - Irving Medical Center, Columbia University - Department of Systems Biology, DarwinHealth, Inc., Memorial Sloan Kettering Cancer Center and Columbia University Irving Medical Center - Department of Systems Biology
Downloads 45 (1,120,871)
Citation 1

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precision cancer medicine, computational inference, drug prediction, patient derived xenograft, high throughput drug screen, protein activity, regulatory network, systems biology, VIPER, OncoTarget, OncoTreat, PLATESeq, breast cancer, sarcoma, meningioma, colon cancer, pancreatic cancer

2.

Network-Based Assessment of HDAC6 Activity is Highly Predictive of Pre-Clinical and Clinical Responses to the HDAC6 Inhibitor Ricolinostat

Number of pages: 45 Posted: 15 Oct 2020
Tizita Zeleke, Qingfei Pan, Codruta Chiuzan, Maika Onishi, Mariano J. Alvarez, Erin Honan, Min Yang, Pei Ling Chia, Partha Mukhopadhyay, Sean Kelly, Ruby Wu, Kathleen Fenn, Meghna Trivedi, Melissa Accordino, Katherine Crew, Dawn Hershman, Matthew Maurer, Simon Jones, Andrea Califano, Kevin Kalinsky, Jiyang Yu and Jose Silva
Icahn School of Medicine at Mount Sinai Hospital - Graduate School, St. Jude Children’s Research Hospital - Department of Computational Biology, Columbia University - Department of Medicine, Genentech, Inc. - San Francisco, DarwinHealth, Inc., Columbia University - Department of Medicine, Acetylon Pharmaceuticals, Icahn School of Medicine at Mount Sinai Hospital - Graduate School, Icahn School of Medicine at Mount Sinai Hospital - Graduate School, Columbia University - Department of Medicine, Columbia University - Department of Medicine, Columbia University - Department of Medicine, Columbia University - Department of Medicine, Columbia University - Herbert Irving Comprehensive Cancer Center, Columbia University - Department of Medicine, Columbia University - Department of Medicine, Bristol Myers Squibb, Regenacy Pharmaceuticals Inc., Columbia University Irving Medical Center - Department of Systems Biology, Columbia University - Department of Medicine, St. Jude Children’s Research Hospital - Department of Computational Biology and Mount Sinai Health System - Department of Oncological Sciences
Downloads 40 (1,182,860)

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Breast Cancer, ricolinostat, HDAC6, clinical trial, biomarker, c-MYC

3.

Network-Based Identification and Pharmacological Targeting of Host Cell Master Regulators Induced by SARS-CoV-2 Infection

Number of pages: 54 Posted: 12 Aug 2021
Pasquale Laise, Megan Stanifer, Gideon Bosker, Xiaoyun Sun, Sergio Triana, Patricio Doldan, Federico La Manna, Marta De Menna, Ronald B. Realubit, Sergey Pampou, Charles Karan, Theodore Alexandrov, Marianna Kruithof-de Julio, Andrea Califano and Mariano J. Alvarez
DarwinHealth, Inc., Heidelberg University - Molecular Virology, DarwinHealth, Inc., DarwinHealth, Inc., European Molecular Biology Laboratory (EMBL) - Germany - Structural and Computational Biology Unit, Heidelberg University Hospital - Virology, University of Bern - Urology Research Laboratory, University of Bern - Urology Research Laboratory, Columbia University - Department of Systems Biology, Columbia University - Department of Systems Biology, Columbia University - Department of Systems Biology, European Molecular Biology Laboratory (EMBL) - Germany - Structural and Computational Biology Unit, University of Bern - Urology Research Laboratory, Columbia University Irving Medical Center - Department of Systems Biology and DarwinHealth, Inc.
Downloads 31 (1,304,153)

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