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Peter A. Sims

Columbia University - Department of Systems Biology

College of Physicians and Surgeons

630 West 168th Street, 3rd Floor, Suite 3-470

New York, NY 10032

United States

SCHOLARLY PAPERS

5

DOWNLOADS

224

TOTAL CITATIONS

3

Scholarly Papers (5)

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1.

A Pharmacological Toolkit for Human Microglia Identifies Topoisomerase I Inhibitors as Immunomodulators for Alzheimer's Disease

Downloads 76 (830,555)
Citation 1

A Pharmacological Toolkit for Human Microglia Identifies Topoisomerase I Inhibitors as Immunomodulators for Alzheimer's Disease

Number of pages: 58 Posted: 12 Mar 2024
Verena Claudia Haage, John F. Tuddenham, Natacha Comandante-Lou, Alex Bautista, Anna Monzel, Rebecca Chiu, Masashi Fujita, Frankie G. Garcia, Prabesh Bhattarai, Ronak Patel, Alice Buonfiglioli, Juan Idiarte, Mathieu Herman, Alison Rinderspacher, Angeliki Mela, Wenting Zhao, Michael Argenziano, Julia L. Furnari, Matei A. Banu, Donald W. Landry, Jeffrey N. Bruce, Peter Canoll, Ya Zhang, Tal Nuriel, Caghan Kizil, Andrew Sproul, Lot D. de Witte, Peter A. Sims, Vilas Menon, Vilas Menon, Martin Picard and Philip L. De Jager
Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Mount Sinai Health System - Department of Psychiatry, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University - Irving Medical Center, Columbia University, Columbia University, Columbia University - Department of Medicine, Columbia University - Irving Medical Center, Columbia University - Department of Pathology and Cell Biology, Columbia University - Irving Medical Center, Columbia University, Columbia University - Taub Institute for Research on Alzheimer's and the Aging Brain, Columbia University, Mount Sinai Health System - Department of Psychiatry, Columbia University - Department of Systems Biology, Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Columbia University Irving Medical Center - Division of Behavioral Medicine and Columbia University - Center for Translational and Systems Neuroimmunology
Downloads 52 (1,060,784)

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Human microglia, single cell, microglia subtypes, in silico drug screening, in vitro models for human microglial subtypes, mitochondrial phenotyping

A Pharmacological Toolkit for Human Microglia Identifies Topoisomerase I Inhibitors as Immunomodulators for Alzheimer's Disease

Number of pages: 54 Posted: 16 Jul 2024
Verena Claudia Haage, John F. Tuddenham, Natacha Comandante-Lou, Alex Bautista, Anna Monzel, Rebecca Chiu, Masashi Fujita, Frankie G. Garcia, Prabesh Bhattarai, Ronak Patel, Alice Buonfiglioli, Juan Idiarte, Mathieu Herman, Alison Rinderspacher, Angeliki Mela, Wenting Zhao, Michael Argenziano, Julia L. Furnari, Matei Banu, Donald W. Landry, Jeffrey N. Bruce, Peter Canoll, Ya Zhang, Tal Nuriel, Caghan Kizil, Andrew Sproul, Lot D. de Witte, Peter A. Sims, Vilas Menon, Vilas Menon, Martin Picard, Philip L. De Jager and Sneak Peek Administrator
Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Mount Sinai Health System - Department of Psychiatry, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University - Irving Medical Center, Columbia University, Columbia University - Department of Pathology and Cell Biology, Columbia University - Department of Medicine, Columbia University - Irving Medical Center, Columbia University - Department of Pathology and Cell Biology, Columbia University - Irving Medical Center, Columbia University, Columbia University - Taub Institute for Research on Alzheimer's and the Aging Brain, Columbia University, Mount Sinai Health System - Department of Psychiatry, Columbia University - Department of Systems Biology, Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Columbia University Irving Medical Center - Division of Behavioral Medicine, Columbia University - Center for Translational and Systems Neuroimmunology and Independent
Downloads 24 (1,445,011)
Citation 1

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Human microglia, single cell, microglia subtypes, in silico drug screening, in vitro models for human microglial subtypes, mitochondrial phenotyping

2.

Heterogeneity of Human Anti-Viral Immunity Shaped by Virus, Tissue, Age, and Sex

Number of pages: 67 Posted: 06 Jul 2021
Maya M.L. Poon, Eve Byington, Wenzhao Meng, Masaru Kubota, Rei Matsumoto, Alba Grifoni, Daniela Weiskopf, Pranay Dogra, Nora Lam, Peter A. Szabo, Basak Burcu Ural, Steven B. Wells, Aaron M. Rosenfeld, Maigan A. Brusko, Todd M. Brusko, Thomas J. Connors, Alessandro Sette, Peter A. Sims, Eline T. Luning Prak, Yufeng Shen and Donna Farber
Columbia University - Department of Microbiology and Immunology, Columbia University - Department of Systems Biology, University of Pennsylvania - Department of Pathology and Laboratory Medicine, Columbia University - Department of Surgery, Columbia University - Department of Surgery, La Jolla Institute for Allergy and Immunology (LIAI) - Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology (LIAI) - Center for Infectious Disease and Vaccine Research, Columbia University - Department of Microbiology and Immunology, Columbia University Irving Medical Center - Department of Pathology and Cell Biology, Columbia University - Department of Microbiology and Immunology, Columbia University - Department of Microbiology and Immunology, Columbia University - Department of Systems Biology, University of Pennsylvania - Department of Pathology and Laboratory Medicine, University of Florida - Department of Pathology, Immunology, and Laboratory Medicine, University of Florida - Department of Pathology, Immunology, and Laboratory Medicine, Columbia University - Department of Pediatrics, La Jolla Institute for Allergy and Immunology (LIAI) - Division of Vaccine Discovery, Columbia University - Department of Systems Biology, University of Pennsylvania - Department of Pathology and Laboratory Medicine, Columbia University - Department of Systems Biology and Columbia University - Department of Microbiology and Immunology
Downloads 51 (1,052,702)

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anti-viral immunity, T cells, tissue immunity, human immunology, cytomegalovirus, influenza, immunological memory

3.

An RNA-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment Resistant Malignancies

Number of pages: 55 Posted: 28 Mar 2022
Prabhjot S. Mundi, Filemon S. Dela Cruz, Adina Grunn, Daniel Diolaiti, Audrey Mauguen, Allison R. Rainey, Kristina C. Guillan, Armaan Siddiquee, Daoqi You, Ronald Realubit, Charles Karan, Michael V. Ortiz, Eugene F. Douglass, Melissa Accordino, Suzanne Mistretta, Frances Brogan, Jeffrey N. Bruce, Cristina I. Caescu, Richard Carvajal, Katherine Crew, Guarionex Decastro, Mark Heaney, Brian Henick, Dawn Hershman, June Hou, Fabio Iwamoto, Joseph Jurcic, Ravi P. Kiran, Michael Kluger, Teri Kreisl, Nicole Lamanna, Andrew Lassman, Emerson Lim, Gulam A. Manji, Guy McKhann, James McKiernan, Alfred I. Neugut, Kenneth Olive, Todd Rosenblat, Gary K. Schwartz, Catherine Shu, Michael Sisti, Ana Tergas, Reena Vattakalam, Mary Welch, Sven Wenske, Jason D. Wright, Hanina Hibshoosh, Kevin M. Kalinsky, Mahalaxmi Aburi, Peter A. Sims, Mariano J. Alvarez, Andrew L. Kung and Andrea Califano
Columbia University - Irving Medical Center, Memorial Sloan Kettering Cancer Center, Columbia University - Irving Medical Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Memorial Sloan Kettering Cancer Center, Columbia University - Department of Systems Biology, Columbia University - Herbert Irving Comprehensive Cancer Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Department of Medicine, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Department of Medicine, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Cambridge, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University, Columbia University - Irving Medical Center, Columbia University - Department of Systems Biology, DarwinHealth, Inc., Memorial Sloan Kettering Cancer Center and Columbia University Irving Medical Center - Department of Systems Biology
Downloads 45 (1,121,190)
Citation 1

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precision cancer medicine, computational inference, drug prediction, patient derived xenograft, high throughput drug screen, protein activity, regulatory network, systems biology, VIPER, OncoTarget, OncoTreat, PLATESeq, breast cancer, sarcoma, meningioma, colon cancer, pancreatic cancer

4.

Activation of ­­STAT3 Through Combined SRC and EGFR Signaling Drives Resistance to a Mitotic Kinesin Inhibitor in Glioblastoma

Number of pages: 58 Posted: 21 Jan 2022
Rajappa Kenchappa, Athanassios Dovas, Michael Argenziano, Christian Meyer, Lauren Stopfer, Matei Banu, Brianna Pereira, Jessica Griffith, Afroz Mohammad, Surabhi Talele, Ashley Haddock, Natanael Zarco, William Elmquist, Forest White, Vito Quaranta, Peter A. Sims, Peter Canoll and Steven S. Rosenfeld
Mayo Clinic - Department of Cancer Biology, Columbia University - Department of Pathology and Cell Biology, Columbia University - Irving Medical Center, Vanderbilt University - Department of Biochemistry, Massachusetts Institute of Technology (MIT) - Department of Biological Engineering, Columbia University - Department of Pathology and Cell Biology, Columbia University - Department of Pathology and Cell Biology, University of Minnesota - Minneapolis - Department of Pharmaceutics, University of Minnesota - Minneapolis - Department of Pharmaceutics, University of Minnesota - Minneapolis - Department of Pharmaceutics, Mayo Clinic - Department of Cancer Biology, Mayo Clinic - Department of Neurosurgery, University of Minnesota - Minneapolis - Department of Pharmaceutics, Massachusetts Institute of Technology (MIT) - Department of Biological Engineering, Vanderbilt University - Department of Biochemistry, Columbia University - Department of Systems Biology, Columbia University - Department of Pathology and Cell Biology and Mayo Clinic - Department of Cancer Biology
Downloads 31 (1,304,549)
Citation 1

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kinesin, glioblastoma, STAT3, inhibitor, EGFR, Src

5.

LIN28B Promotes Collective Cell Invasion and Colorectal Cancer Metastasis via the Induction of CLDN1 and NOTCH3

Number of pages: 65 Posted: 29 Sep 2022
Yasunori Masuike, Kensuke Sugiura, Kensuke Suzuki, Alice Eunjung Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner and Anil K. Rustgi
Columbia University - Herbert Irving Comprehensive Cancer Center, Columbia University - Herbert Irving Comprehensive Cancer Center, Columbia University - Herbert Irving Comprehensive Cancer Center, Columbia University - Herbert Irving Comprehensive Cancer Center, Chiba University - Department of General Surgery, Chiba University - Department of Frontier Surgery, Chiba University - Department of General Surgery, Columbia University - Department of Systems Biology, University of Pennsylvania - Department of Biomedical Sciences and Columbia University - Herbert Irving Comprehensive Cancer Center
Downloads 21 (1,436,435)

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LIN28B, CLDN1, collective cell invasion, colon cancer progression, cancer metastasis