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Philip L. De Jager

Columbia University - Center for Translational and Systems Neuroimmunology

630 West 168th Street, 3rd Floor, Suite 3-470

New York, NY 10032

United States

SCHOLARLY PAPERS

8

DOWNLOADS

1,305

TOTAL CITATIONS

19

Scholarly Papers (8)

1.

Defining Microglial States and Nomenclature: A Roadmap to 2030

Number of pages: 44 Posted: 23 Mar 2022
University of Lausanne - Department of Biomedical Sciences, Achucarro Basque Center for Neuroscience, Broad Institute of Harvard and MIT - Stanley Center for Psychiatric Research, University of Victoria, University of Zurich - Institute of Neuropathology, Oregon Health and Science University - Department of Molecular Microbiology and Immunology, Weizmann Institute of Science - Department of Immunology, University of Montpellier - Institut de Génomique Fonctionnelle (IGF), University of Leipzig - Institute of Anatomy, University of Pennsylvania - Children's Hospital of Philadelphia, University of Pennsylvania - Children's Hospital of Philadelphia, École Normale Supérieure (ENS), AbbVie Deutschland GmbH & Co. KG - Neuroscience Discovery, Duke University - Department of Psychology and Neuroscience, University of California, Irvine - Center for the Neurobiology of Learning and Memory, University of Groningen - Department of Biomedical Sciences of Cells & Systems, University of Lisbon - Research Institute for Medicines (iMed.ULisboa), Hasselt University - Biomedical Research Institute, University of Cambridge - Department of Biochemistry, Harvard University - Ann Romney Center for Neurologic Diseases, University of California, Riverside (UCR) - Center for Glial-Neuronal Interactions, Fisiología e Inmunología - Unidad de Histología Medica, Washington University in St. Louis - Department of Pathology and Immunology, University of Oxford - James and Lillian Martin Centre for Stem Cell Research, Trinity College (Dublin) - School of Biochemistry and Immunology, Cleveland Clinic - Department of Neurosciences, Columbia University - Center for Translational and Systems Neuroimmunology, University College London - Bart de Strooper, Hungarian Academy of Sciences (HAS) - “Momentum” Laboratory of Neuroimmunology, University of Groningen - Department of Biomedical Sciences of Cells & Systems, Mayo Clinic - Department of Neurology, Autonomous University of Barcelona - Institut de Neurociències and Departament de Bioquímica, École Normale Supérieure - PSL Research University - Institute of Biology of the Ecole Normale Supérieure (IBENS), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), University of California, San Diego (UCSD) - Department of Cellular & Molecular Medicine, Ludwig Maximilian University of Munich (LMU) - Institute for Stroke and Dementia Research, University of Southampton - School of Biological Sciences, Fisiología e Inmunología - Unidad de Histología Medica, University of Oxford - Sir William Dunn School of Pathology, The University of Sydney - Ken Parker Brain Tumour Research Laboratories, Brain and Mind Centre, The University of Manchester - Lydia Becker Institute of Immunology and Inflammation, University of Paris - INSERM, University of Zurich - Institute of Experimental Immunology, Washington University in St. Louis - School of Medicine, Universite du Luxembourg - Luxembourg Centre for Systems Biomedicine, University of Bonn - Department of Neurodegenerative Disease and Gerontopsychiatry, Charité - Universitätsmedizin Berlin - Institute for Neuropathology, University College London - UK Dementia Research Institute, Weizmann Institute of Science - Department of Immunology, Helmholtz Association of German Research Centres - Max Delbrück Center for Molecular Medicine, University of Virginia - Department of Neuroscience, University of Tokyo - Laboratory of Chemical Pharmacology, Salk Institute for Biological Studies - Molecular Neurobiology Laboratory, Trinity College (Dublin) - Institute of Neuroscience, University of Rochester - Department of Neuroscience, King’s College London - Wolfson Centre for Age-Related Diseases, University of Eastern Finland - A.I. Virtanen Institute for Molecular Sciences, University of Antwerp - Department of Biomedical Sciences, Humanitas University - Department of Biomedical Sciences, UK Dementia Research Institute, University of Edinburgh - MRC Centre for Reproductive Health, University of California, San Francisco (UCSF), University of California, Berkeley - Howard Hughes Medical Institute (HHMI), Discovery Pharmacology - Roche Innovation Center Zurich, University of Bordeaux - Neurocentre Magendie, German Center for Neurodegenerative Diseases (DZNE), Vilnius University - VU LSC-EMBL Partnership for Genome Editing Technologies, University of Bonn - Institute of Reconstructive Neurobiology, Kyushu University - Laboratory of Pathophysiology, Fudan University - Department of Neurosurgery, University of Zurich - Department of Molecular Life Sciences, UK Dementia Research Institute, Ohio State University (OSU) - Department of Neuroscience, Technische Universität München (TUM) - Department of Psychiatry & Psychotherapy, Sapienza University of Rome - Department of Physiology and Pharmacology, Third Rock Ventures, University of Toronto - The Hospital for Sick Children - SickKids, Mount Sinai Health System - Nash Department of Neuroscience, University of Massachusetts Worcester - Department of Neurobiology, Weizmann Institute of Science - Department of Neurobiology, German Center for Neurodegenerative Diseases (DZNE) - Institute of Neuronal Cell Biology, University of Florida - Division of Neuroscience, University of Freiburg - Faculty of Biology, Massachusetts Institute of Technology (MIT) - The Picower Institute for Learning and Memory, Celica Biomedical, Universidad San Sebastian - Faculty of Health Sciences, Nagoya University - Department of Anatomy and Molecular Cell Biology, Université Libre de Bruxelles (ULB) - Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Charité Universitätsmedizin Berlin, Mayo Clinic - Department of Neurology and Stanford University - Department of Neurology and Neurological Sciences
Downloads 992 (57,281)
Citation 18

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A Pharmacological Toolkit for Human Microglia Identifies Topoisomerase I Inhibitors as Immunomodulators for Alzheimer's Disease

Number of pages: 58 Posted: 12 Mar 2024
Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Mount Sinai Health System - Department of Psychiatry, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University - Irving Medical Center, Columbia University, Columbia University, Columbia University - Department of Medicine, Columbia University - Irving Medical Center, Columbia University - Department of Pathology and Cell Biology, Columbia University - Irving Medical Center, Columbia University, Columbia University - Taub Institute for Research on Alzheimer's and the Aging Brain, Columbia University, Mount Sinai Health System - Department of Psychiatry, Columbia University - Department of Systems Biology, Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Columbia University Irving Medical Center - Division of Behavioral Medicine and Columbia University - Center for Translational and Systems Neuroimmunology
Downloads 52 (1,060,784)

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Human microglia, single cell, microglia subtypes, in silico drug screening, in vitro models for human microglial subtypes, mitochondrial phenotyping

A Pharmacological Toolkit for Human Microglia Identifies Topoisomerase I Inhibitors as Immunomodulators for Alzheimer's Disease

Number of pages: 54 Posted: 16 Jul 2024
Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Mount Sinai Health System - Department of Psychiatry, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University, Columbia University - Irving Medical Center, Columbia University, Columbia University - Department of Pathology and Cell Biology, Columbia University - Department of Medicine, Columbia University - Irving Medical Center, Columbia University - Department of Pathology and Cell Biology, Columbia University - Irving Medical Center, Columbia University, Columbia University - Taub Institute for Research on Alzheimer's and the Aging Brain, Columbia University, Mount Sinai Health System - Department of Psychiatry, Columbia University - Department of Systems Biology, Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Columbia University Irving Medical Center - Division of Behavioral Medicine, Columbia University - Center for Translational and Systems Neuroimmunology and Independent
Downloads 24 (1,445,011)
Citation 1

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Human microglia, single cell, microglia subtypes, in silico drug screening, in vitro models for human microglial subtypes, mitochondrial phenotyping

3.

Multi-Omic Characterization of Brain Changes in the Vascular Endothelial Growth Factor Family During Aging and Alzheimer's Disease

Number of pages: 29 Posted: 07 Nov 2022
Vanderbilt University, Vanderbilt University - Medical Center, Vanderbilt University - Medical Center, Vanderbilt University - Medical Center, Columbia University - Center for Translational and Systems Neuroimmunology, Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Stanford Hospital, Vanderbilt University - Medical Center, Vanderbilt University - Vanderbilt Genetics Institute, Vanderbilt University - Vanderbilt Genetics Institute, Emory University - Department of Biochemistry, Vanderbilt University - Medical Center, Rush University - Alzheimer’s Disease Center, Rush University - Alzheimer’s Disease Center, Government of the United States of America - Pacific Northwest National Laboratory and Vanderbilt University - Medical Center
Downloads 55 (1,010,164)

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VEGF, Alzheimer's disease, proteomics, transcriptomics, cognition

4.

Cell Type- and State- Resolved Immune Transcriptomic Profiling Identifies Glucocorticoid-Responsive Molecular Defects in Multiple Sclerosis T Cells

Number of pages: 35 Posted: 08 Nov 2022
Columbia University - Center for Translational and Systems Neuroimmunology, Columbia University - Center for Translational and Systems Neuroimmunology, Harvard University - Alzheimer’s Clinical and Translational Research Unit, Harvard University - Ann Romney Center for Neurologic Diseases, Harvard University - Ann Romney Center for Neurologic Diseases, Krembil Centre for Neuroinformatics - Centre for Addiction and Mental Health, Columbia University - Center for Translational and Systems Neuroimmunology, Harvard University - Systems Biology and Computer Science Program, Harvard University - Systems Biology and Computer Science Program, Sorbonne University, Harvard University - Systems Biology and Computer Science Program, Harvard Medical School and Brigham and Women's Hospital - Evergrande Center for Immunologic Diseases, Sorbonne University - Institut du Cerveau-Paris Brain Institute (ICM), Harvard Medical School - Ann Romney Center for Neurologic Diseases, Columbia University - Center for Translational & Computational Neuroimmunology and Columbia University - Center for Translational and Systems Neuroimmunology
Downloads 43 (1,145,425)

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Multiple sclerosis, transcriptomics, weighted gene co-expression network analysis, glucocorticoid receptor agonists, T cell, monocyte, ex vivo state, in vitro stimulation, ZBTB16

5.

Relation of CMV and Brain Atrophy to Trajectories of Immunosenescence in Diverse Populations

Number of pages: 51 Posted: 30 Oct 2024
Columbia University - Center for Translational and Systems Neuroimmunology, Columbia University - Irving Medical Center, Columbia University, Columbia University - Irving Medical Center, Columbia University, Columbia University - Vagelos College of Physicians and Surgeons (P&S), Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, University of Pennsylvania - Center for Neuroinflammation and Experimental Therapeutics, McGill University, University of Pittsburgh, University of Pittsburgh, McGill University - McGill University Health Centre, Columbia University - Irving Medical Center, Columbia University - Irving Medical Center, University Hospital Münster - Clinic of Neurology with Institute of Translational Neurology, University Hospital Münster - Clinic of Neurology with Institute of Translational Neurology, University of Pittsburgh - Department of Neurology, University of Pennsylvania - Center for Neuroinflammation and Experimental Therapeutics, Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Columbia University - Irving Medical Center, Columbia University - Center for Translational and Systems Neuroimmunology and Independent
Downloads 40 (1,183,237)

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Immunosenescence, African Americans, Hispanics, Non-Hispanic whites, immune-age estimate, NK cells, CMV, brain atrophy.

6.

Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain

Number of pages: 59 Posted: 28 Jul 2021
Columbia University Irving Medical Center - Division of Behavioral Medicine, Columbia University Irving Medical Center - Department of Physiology and Cellular Biophysics, Columbia University - Center for Translational & Computational Neuroimmunology, Columbia University Irving Medical Center - Center for Translational & Computational Neuroimmunology, Pacific Northwest National Laboratory, Emory University - Department of Neurology, Government of the United States of America - Division of Mental Health, National Institute on Aging Intramural Research Program - Clinical and Translational Neuroscience Section, Government of the United States of America - Translational Gerontology Branch, Emory University - Department of Biochemistry, Rush University - Alzheimer’s Disease Center, Columbia University - Center for Translational and Systems Neuroimmunology and Columbia University Irving Medical Center - Division of Behavioral Medicine
Downloads 39 (1,196,171)

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Mitochondrial respiratory chain, post-mortem brain, Alzheimer disease, proteomics, ROSMAP, BLSA, Banner

7.

A Structured Evaluation of Cryopreservation in Generating Single Cell Transcriptomes From Cerebrospinal Fluid

Number of pages: 38 Posted: 01 Oct 2021
Columbia University - Center for Translational and Systems Neuroimmunology, Columbia University - Center for Translational and Systems Neuroimmunology, Roche - Neuroscience and Rare Diseases (NRD), Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Columbia University - Irving Medical CenterColumbia University - Columbia Multiple Sclerosis Center, Roche - gRED OMNI-Biomarker Development, Roche - Product Development Medical Affairs (PDMA) Neuroscience, University of Basel - Department of Neurology and Biomedicine, Roche - Neuroscience and Rare Diseases (NRD), Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, University of Basel - Department of Neurology and Biomedicine, Columbia University - Center for Translational and Systems Neuroimmunology and Roche - Neuroscience and Rare Diseases (NRD)Roche - Neuroscience and Rare Diseases (NRD)
Downloads 31 (1,304,549)

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CSF, sc-RNA-Seq, Transcriptomics, Neuroinflammation

8.

Genetic Predisposition to Hand Grip Weakness Predicts Cognitive Decline

Number of pages: 37 Posted: 07 Jul 2025
affiliation not provided to SSRN, University of Toronto, Krembil Centre for Neuroinformatics - Centre for Addiction and Mental Health, University of Toronto, University of the Fraser Valley, Columbia University - Center for Translational and Systems Neuroimmunology, Rush University - Alzheimer’s Disease Center, Rush University - Rush University Medical Center, Rush University - Alzheimer’s Disease Center, University of Toronto, University of Toronto and University of Toronto
Downloads 29 (1,332,057)

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polygenic risk score, Alzheimer's disease, cognitive decline, hand grip strength, muscular fitness, mediation, postmortem neuropathology