affiliation not provided to SSRN, University of Toronto, Krembil Centre for Neuroinformatics - Centre for Addiction and Mental Health, University of Toronto, University of the Fraser Valley, Columbia University - Center for Translational and Systems Neuroimmunology, Rush University - Alzheimer’s Disease Center, Rush University - Rush University Medical Center, Rush University - Alzheimer’s Disease Center, University of Toronto, University of Toronto and University of Toronto