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Jean C. Y. Wang

University of Toronto - Princess Margaret Cancer Centre

610 University Avenue

Toronto, ON M5G 2M9

Canada

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Scholarly Papers (1)

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Nicotinamide Phosphoribosyltransferase Inhibitors Selectively Induce Apoptosis of AML Stem Cells by Disrupting Lipid Homeostasis

Number of pages: 78 Posted: 20 Oct 2020
Amit Subedi, Qiang Liu, David Sharon, Severine Cathelin, Changjiang Xu, Veronique Voisin, Gary D. Bader, Angelo D’Alessandro, Eric R. Lechman, John E. Dick, Mark Minden, Jean C. Y. Wang and Steven M. Chan
University Health Network - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Department of Molecular Genetics, University of Colorado, Aurora - Department of Biochemistry and Molecular Genetics, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre and University of Toronto - Princess Margaret Cancer Centre
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Abstract:

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acute myeloid leukemia, leukemic stem cells, drug screen, Metabolism, NAMPT, NAD metabolism, SREBP signaling, lipotoxicity, fatty acid, dipyridamole, drug combination